Results 121 to 130 of about 99,751 (297)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

CREEP OF POLYCRYSTALLINE IRON UNDER SMALL TORSIONAL STRESS AND THE EFFECT OF CARBON UPON THE CREEP

, 1954
KE TING-SUI, KUNG CHING-PING
openalex   +1 more source

Closure to “Discussion of ‘Correlation of Creep Properties by a Diffusion Analogy’” (1953, ASME J. Appl. Mech., 20, pp. 146–147) [PDF]

, 1953
León Green
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Creep Deformation of a Mild Steel under Stepwise Varying Periodic Stresses

, 1958
Toshio NISHIHARA, Shuji TAIRA, Kichinosuke TANAKA, Kiyotsugu OHJI   +3 more
openalex   +2 more sources

Discussion: “Progress Report on Tubular Creep Tests” (Norton, F. H., 1941, Trans. ASME, 63, pp. 735–736) and “Interpretation of Creep Tests on Tubes” (Soderberg, C. R., 1941, Trans. ASME, 63, pp. 737–740) [PDF]

, 1941
Ernest L. Robinson
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Brittle Fracture in Creep Rupture Test of Some Heat-Resisting Steels

, 1959
Masao Kanamori, Teishirô Oda
openalex   +2 more sources

Discussion: “The Interpretation of Creep Tests for Machine Design” (Soderberg, C. Richard, 1936, Trans. ASME, 58, pp. 733–743) [PDF]

, 1937
Joseph Marin
openalex   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source