Results 131 to 140 of about 542,843 (395)

Creep Strain and Strain Rate Response of 2219 Al Alloy at High Stress Levels [PDF]

, 2000
Karen M. Taminger, John A. Wagner, W. B. Lisagor   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Columnar defects and vortex fluctuations in layered superconductors

, 1995
We investigate fluctuations of Josephson-coupled pancake vortices in layered superconductors in the presence of columnar defects. We study the thermodynamics of a single pancake stack pinned by columnar defects and obtain the temperature dependence of ...
A. Buzdin, A. E. Koshelev, C.J. van der Beek, D.R. Nelson, D.R. Nelson, G.S. Mkrtchyan, H. Pastoriza, J. Blatter, L. Civale, L. Klein, L. Krusin-Elbaum, L.I. Glazman, L.L. Daemen, M. Konczykowski, M. Konczykowski, P. Le Doussal, R.P. Feynman, S. Ryu, V. M. Vinokur, W. Gerhäuser, W.R. White, W.R. White   +21 more
core   +1 more source

Discussion of “Creep Buckling of Reinforced Concrete Columns” [PDF]

, 1964
A. S. Hall
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A creep model for metallic composites based on matrix testing: Application to Kanthal composites [PDF]

An anisotropic creep model is formulated for metallic composites with strong fibers and low to moderate fiber volume percent (less than 40 percent).
Arnold, S. M., Bartolotta, Paul A., Binienda, W. K., Robinson, D. N.   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Creep failure characteristics and damage creep model of red layer soft rock based on Perzyna viscoplastic theory

Scientific Reports
Rock creep is essentially a process of damage accumulation. According to the damage evolution of rock under creep conditions, the TAW2000 triaxial test system is used to carry out triaxial creep test on red layer soft rock taken from Yibo Tunnel in ...
Lei Chen, Jinchi Han, Shuguang Zhang, Jiaxu Jin, Baoxin Jia, Jiashun Liu, Jupeng Tang   +6 more
doaj   +1 more source

The development of advanced creep constitutive equations for high chromium steel P91 at low stress range [PDF]

, 2013
Diffusion dominates the creep deformation at low stress range for high chromium steel P91. Brittle creep fracture is caused by cavity nucleation, growth and coalescence of cavities and large precipitates (Laves phase and M23C6) at grain boundary under ...
An, Lili, Lu, Zhongyu, Xu, Qiang
core