Results 131 to 140 of about 99,412 (322)

Creep Deformation of a Mild Steel under Stepwise Varying Periodic Stresses

, 1958
Toshio Nishihara, Shuji TAIRA, Kichinosuke TANAKA, Kiyotsugu OHJI   +3 more
openalex   +2 more sources

CORRESPONDENCE ON RAIL CREEP. [PDF]

, 1918
J. B. Ball, W G COUGHLIN, W DAWSON, R W EGERTON, Ann Elder, J M R FAIRBAIRN, Chris Hogg, Hamish Jackson, P. H. Johnson, A E LANGLEY, J N D LA TOUCHE, SIR B LESLIE, Colin Jones, E J NEACHELL, A C RENTON, J ROWLANDSON, R. Sexton, H SHERLOCK, E W STONEY, J G SULLIVAN, C H SUMMER, J S TODD   +21 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Brittle Fracture in Creep Rupture Test of Some Heat-Resisting Steels

, 1959
Masao Kanamori, Teishirô Oda
openalex   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Creep Used Varying Stresses

, 1959
Kiyotsugu OHJI
openalex   +2 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

New flat-punch indentation creep testing approach for characterizing the local creep properties at high temperatures

Materials & Design, 2019
An indentation creep testing approach has been developed which allows measuring creep properties at high temperatures. In contrast to existing indentation or impression creep experiments, the approach described here allows to achieve a quite high spatial
D. Matschkal-Amberger, M. Kolb, S. Neumeier, S. Gao, A. Hartmaier, K. Durst, M. Göken   +6 more
doaj  

Creep and Recovery Properties of Terylene Fibers

, 1959
Yoshio Yamaguchi
openalex   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source