Results 181 to 190 of about 542,843 (395)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Research on Creep Behaviors of GH3230 Superalloy Sheets with Side Notches. [PDF]
Materials (Basel)Zhao H, Cheng D, Chen M, Xiao W, Hou C.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Adequacy of Standard Models for Long-Term Behavior of Lightweight Concrete with Sintered Aggregate Under Cyclic Loading. [PDF]
Materials (Basel)Lewiński PM +3 more
europepmc +1 more source
Thermal Chamber for Adhesives Creep Multi-Station Testing Machine
, 2020 Manuel Brito Janeira +3 more
openalex +2 more sources
Viscoelastic Analysis of Asphalt Mixture Based on Creep Test [PDF]
, 2013 Lihua Zhao, Jingyun Chen, Shengwu Wang
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Structural Effects of Concrete Creep in a Prestressed Balanced Cantilever Bridge Based on Classical and Fractional Rheological Models. [PDF]
Materials (Basel)Nowak K, Oleszek R, Zbiciak A.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source