Results 231 to 240 of about 4,982 (304)

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Experimental study on creep mechanical properties and failure modes of anthracite in dry and saturated states. [PDF]

Sci Rep
Zhang X, Yan J, Wang K, Yue S, Zhang F, Wang W.   +5 more
europepmc   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Topics and Insights on 1-D Tension Stiffening of an RC Member. [PDF]

Materials (Basel)
Yankelevsky DZ, Karinski YS, Tsemakh D, Feldgun VR.   +3 more
europepmc   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

A Numerical Investigation on the Influence of Film-Cooling Hole Inclination Angle on the Stress Field of Surrounding Thermal Barrier Coating. [PDF]

Materials (Basel)
Shi Z, Jia Y, He X, Tian Z, Liu Y.
europepmc   +1 more source

Subcritical cracking and sealing along cleavage planes and subgrain boundaries in plagioclase from the Mado Megamullion oceanic core complex. [PDF]

Sci Rep
Nimura K, Okudaira T, Michibayashi K.
europepmc   +1 more source

The Development of Finite Element Analysis Software for Creep Damage Analysis

, 2013
Tan, Feng, Xu, Qiang, Xu, Donglai, Liu, Dezheng, Lu, Zhongyu, Xu, Dong Lai   +5 more
core  

Gas Turbine Blade Failures Repaired Using Laser Metal Additive Remanufacturing. [PDF]

Materials (Basel)
Chen C, Zhang M, Liu H, Yang Q.
europepmc   +1 more source