Results 71 to 80 of about 1,597,650 (363)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Kansas Agricultural Experiment Station Research Reports, 2007 The objective of this experiment was to determine the effects of different creep feeder designs and increased feed accessibility on creep feed consumption and pre-weaning performance. A total of 54 sows (PIC Line 1050) and their litters were used in this study. Two groups of sows were blocked according to parity and date of farrowing using a randomized
R C Sulabo +6 more
openaire +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2006 Avaliou-se o efeito da suplementação de bezerros em sistema de creep feeding, em pastagens de Brachiaria brizantha, durante o período de amamentação, sobre o ganho médio diário (GMD), peso à desmama (PD) e taxa de gestação, em delineamento inteiramente ...
E. Nogueira +5 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Creep feed grinding with continuous dressing.
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1985 Greep feed grinding is an effective technology to increase the productivity of form grinding. This method has, however, some problems which are mainly caused by the remarkable change of the wheel surface topography during grinding process. Namely, development of the attritious wear of grain cutting edge is severe, which makes it difficult to grind a ...
Yutaka ARAKI +3 more
openaire +2 more sources
Ecological study of aquatic midges and some related insects with special reference to feeding habits [PDF]
, 1922 Die Schweiz ist ein reiches Land. Sie verfügt über viele Millionäre. Der große Reichtum konzentriert sich auf wenige Familien und Personen. In der Schweiz leben aber auch eine halbe Million der Bevölkerung (7,5 Mio.) in Haushalten von Erwerbstätigen, die
A. Diezinger +19 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source