Results 71 to 80 of about 37,908 (346)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Foram utilizados 32 bezerros lactentes da raça Canchim, mantidos em sistema de pastejo rotativo de Brachiaria brizantha cv. Marandu, divididos em três grupos correspondentes aos tratamentos avaliados: controle (sem creep-feeding); SAL5 (adição de 5% de ...
Sampaio Alexandre Amstalden Moraes +5 more
doaj
The role of glacier mice in the invertebrate colonisation of glacial surfaces: the moss balls of the Falljökull, Iceland [PDF]
Glacier surfaces have a surprisingly complex ecology. Cryoconite holes contain diverse invertebrate communities while other invertebrates, such as Collembola often graze on algae and windblown dead organic on the glacier surface.
A Babenko +40 more
core +1 more source
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Este trabalho objetivou avaliar o comportamento ingestivo e o consumo de forragem de cordeiros em sistemas de terminação a pasto. Os tratamentos foram: cordeiros mantidos junto às ovelhas em pastagem de azevém sem suplementação; cordeiros mantidos junto ...
Hugo Von Linsingen Piazzetta +5 more
doaj
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
Desempenho reprodutivo de borregas da raça Suffolk criadas com suplementação em comedouro privativo
Com o objetivo de avaliar o efeito dos níveis de suplementação com concentrado contendo 25 % de PB e 3,18 Mcal EM kg-1 MS-1 para cordeiras em pastagem com comedouro privativo sobre o peso e desempenho em distintas idades, início da puberdade e desempenho
Jessé Siqueira Ortiz +6 more
doaj +1 more source
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source

