Results 31 to 40 of about 861 (237)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The effects of DS blade׳s geometry features on material׳s creep strength

Propulsion and Power Research, 2014
Because of the better creep performance, the directional solidification (DS) Nickel-based turbine blades have been widely used in advanced aero-engines.
Xiaojun Yan, Kai Zhang, Ying Deng, Ruijie Sun, Lianshan Lin, Xiaoyong Zhang   +5 more
doaj   +1 more source

Performance and Life Assessment of Reformer Tubes in Petrochemical Industries

High Temperature Materials and Processes, 2014
High temperature mechanical properties of service exposed reformer tubes are compared and revalidated with those of virgin material for the sake of health assessment studies.
Raj A., Goswami B., Kumar S.B., Krishna G., Roy N., Ray A.K.   +5 more
doaj   +1 more source

History-sensitive accumulation rules for life-time prediction under variable loading

, 2011
This is the post-print version of the article. The official published version can be obtained from the link below - Copyright @ 2011 SpringerA general form of temporal strength conditions under variable creep loading is employed to formulate several new ...
Mikhailov, SE, S. E. Mikhailov, I. V. Namestnikova, Namestnikova, IV   +3 more
core   +1 more source

Creep life prediction of P91 steel using omega method [PDF]

, 2023
Martensitic P91 steel is desirable for structural components operating at elevated temperatures. It is extensively used in nuclear power plant boilers, pipelines, reactor pressure vessels, and steam generators due to its high creep strength and corrosion
M. R., Mahazar, Norhaida, Ab. Razak, S. N. A., Rosli, N. A., Alang   +3 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

An evaluation of operation and creep life of stationary gas turbine engine [PDF]

, 2012
During operation, gas turbine components undergo various types of timedependent degradation due to high temperatures and mechanical loading. In the case of stationary GT engines for mechanical power, creep failure mechanism problems are a very common ...
Eshati, Samir
core  

The Interpretation of Experimental Observation Data for the Development of Mechanisms based Creep Damage Constitutive Equations for High Chromium Steel

, 2015
It is very important to design a safe factor or estimating the remain lifetime for electric power plant components of steam pipes which mostly manufacture by high chromium steels and work at high temperature and low stress level.
Yang, Xin, Xu, Qiang, Xin Yang, Zhongyu Lu, Qiang Xu, Lu, Zhongyu   +5 more
core   +1 more source