Results 81 to 90 of about 14,538,904 (339)

The equatorial ionospheric anomaly in electron content from solar minimum to solar maximum for South East Asia [PDF]

open access: yesAnnales Geophysicae, 1994
Median hourly, electron content-latitude profiles obtained in South East Asia under solar minimum and maximum conditions have been used to establish seasonal and solar differences in the diurnal variations of the ionospheric equatorial anomaly (EIA ...
G. O. Walker, J. H. K. Ma, E. Golton
doaj   +1 more source

Near-bed hydrodynamics and turbulence below a large-scale plunging breaking wave over a mobile barred bed profile [PDF]

open access: yes, 2016
Funded by The research presented in this paper is part of the SINBAD project.
Caceres, I   +5 more
core   +8 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Spatiotemporal structure of cell fate decisions in murine neural crest [PDF]

open access: yes, 2019
Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube ...
Bronner, Marianne   +2 more
core  

Dissecting early regulatory relationships in the lamprey neural crest gene network [PDF]

open access: yes, 2008
The neural crest, a multipotent embryonic cell type, originates at the border between neural and nonneural ectoderm. After neural tube closure, these cells undergo an epithelial–mesenchymal transition, migrate to precise, often distant locations, and ...
Basch   +22 more
core   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Pax7 lineage contributions to the mammalian neural crest.

open access: yesPLoS ONE, 2012
BackgroundNeural crest cells are vertebrate-specific multipotent cells that contribute to a variety of tissues including the peripheral nervous system, melanocytes, and craniofacial bones and cartilage.
Barbara Murdoch   +2 more
doaj   +1 more source

Are rogue waves really unexpected?

open access: yes, 2016
An unexpected wave is defined by Gemmrich & Garrett (2008) as a wave that is much taller than a set of neighboring waves. Their definition of "unexpected" refers to a wave that is not anticipated by a casual observer. Clearly, unexpected waves defined in
Fedele, Francesco
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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