Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens [PDF]
Nature Communications, 2023 CreTA, CRISPR-regulated toxin-antitoxin (TA), safeguards CRISPR-Cas immune systems by inducing cell dormancy/death upon their inactivation. Here, we characterize a bacterial CreTA associating with the I-F CRISPR-Cas in Acinetobacter.
Rui Wang +11 more
doaj +2 more sources
Similar Levels of Disease Severity Correspond to a Greater Burden of Illness in Women Compared with Men with Hidradenitis Suppurativa [PDF]
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Tonia Samela +7 more
doaj +2 more sources
Comprehensive Overview of Cytokine Interplay in Vitiligo: A Decade of Meta-Analyses Systematically Reviewed [PDF]
Life(1) Background: Vitiligo is an autoimmune skin disorder characterized by melanocyte destruction. Despite metabolic disturbances and oxidative stress also playing a key role in its pathogenesis, accumulating evidence highlights a prominent role for ...
Alessia Paganelli +6 more
doaj +2 more sources
Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists
Biomolecules, 2021 Background: Systemic photoprotection (i.e., administration of substances such as nicotinamide, carotenoids, and vitamin D) may be important to reduce photocarcinogenesis or to support long-term protection against UV irradiation.
Luca Fania +11 more
doaj +1 more source
Systemic Photoprotection in Melanoma and Non-Melanoma Skin Cancer
Biomolecules, 2023 Non-melanoma skin cancers (NMSCs), which include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and actinic keratosis (AK), are the most common cancer diseases in the Caucasian race.
Mariafrancesca Hyeraci +11 more
doaj +1 more source
Conservative Surgical Management of Placenta Accreta Spectrum: A Pragmatic Approach
Journal of Investigative Surgery, 2021 In the last 30 years, with increasing cesarean section rates, the incidence of the placenta accreta spectrum has also increased. It is estimated that by the year 2020 there will be nearly 9000 cases annually in the United States.
Joanna Sichitiu +3 more
doaj +1 more source
Cells, 2021 The phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is aberrantly activated in psoriatic lesions and contributes to disease pathogenesis.
Laura Mercurio +6 more
doaj +1 more source
Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches
Biomedicines, 2020 Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an aging population and widespread sun exposure.
Luca Fania +10 more
doaj +1 more source
microRNAs involved in psoriasis and cardiovascular diseases
Vascular Biology, 2021 Psoriasis is a chronic inflammatory disease involving the skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different comorbidities
Sara Sileno +5 more
doaj +1 more source
Cutaneous Squamous Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches
Biomedicines, 2021 Cutaneous squamous cell carcinoma (cSCC), a non-melanoma skin cancer, is a keratinocyte carcinoma representing one of the most common cancers with an increasing incidence. cSCC could be in situ (e.g., Bowen’s disease) or an invasive form.
Luca Fania +12 more
doaj +1 more source