Results 221 to 230 of about 305,599 (299)

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

open access: yesDrug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche   +5 more
wiley   +1 more source

Effect of Reaction Time and Temperature on the Impurity Profile of Amphetamine in the Leuckart Method

open access: yesDrug Testing and Analysis, EarlyView.
This study investigates the effect of the reaction temperature (step 1) and reaction time (step 1 and 2) on the conversion efficiency and impurity profile of amphetamine synthesized via the Leuckart method. Conversion efficiency and impurity profile were assessed using gas chromatography–flame ionization detection (GC–FID) and GC–mass spectrometry (GC ...
Maartje C. M. Verhoeven   +7 more
wiley   +1 more source

Chemical Straightening as a Source of Analytical Variability in Hair Testing: A Dual‐Analyte Case Report

open access: yesDrug Testing and Analysis, EarlyView.
ABSTRACT Hair analysis is increasingly used in forensic toxicology; however, result interpretation may be influenced by cosmetic hair treatments. Although the effects of bleaching, dyeing, and thermal straightening have already been evaluated, data on permanent chemical hair straightening are scarce, particularly under in vivo conditions.
Miriam Blanco‐Ces   +5 more
wiley   +1 more source

Segmental Hair Analysis of Diphenhydramine and Cyclizine Following a Single Dose

open access: yesDrug Testing and Analysis, EarlyView.
A single oral dose of diphenhydramine and cyclizine can be quantified in human head hair for a minimum of 5 months and, in certain cases, for up to 1 year following intake. Among 12 study participants, the measured concentrations ranged from 0 to 610 pg/mg within 1 year post‐intake.
Jan Bílek   +3 more
wiley   +1 more source

Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Gene transcription is crucial for embryo and postnatal development and is regulated by the Mediator complex. Mediator is comprised of four submodules, including the kinase submodule (CKM). The CKM consists of MED13, MED12, CDK8, and CCNC.
Anna K. Leinheiser   +5 more
wiley   +1 more source

Skin Shade Discrimination Is Associated With Disordered Weight Control Behaviors in Hong Kong, Malaysia, Singapore, and Thailand

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Emerging evidence indicates that experiencing discrimination is associated with disordered eating. This study aimed to test the association between experiences of colorism (skin shade discrimination penalizing those with darker skin) and the prevalence of disordered weight control behaviors (DWCBs) in four Asian countries/regions ...
Nadia Craddock   +5 more
wiley   +1 more source

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