Results 191 to 200 of about 159,909 (301)

CD248/Endosialin Regulates Synovial Fibroblast State to Control Coupling of Inflammation and Bone Damage in Murine Models of Immune‐Mediated Inflammatory Arthritis and Aging

open access: yesArthritis &Rheumatology, EarlyView.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble   +12 more
wiley   +1 more source

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Real‐world initial treatment strategies in SSc‐PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. Methods We analysed treatment‐naïve SSc‐PAH patients in EUSTAR (2000–2021) fulfilling the 2022 haemodynamic definition.
Hilde Jenssen Bjørkekjær   +30 more
wiley   +1 more source

Sustained Inhibition of Structural Damage Progression and Improvements in Disease Activity With Guselkumab in Biologic‐Naïve Participants with Active and Erosive Psoriatic Arthritis: Results Through Week 48 of the Phase 3b Randomized, Double‐Blind, Placebo‐Controlled APEX Study

open access: yesArthritis &Rheumatology, Accepted Article.
Objective In APEX, guselkumab, which binds to the IL‐23p19 subunit and CD64 on IL‐23‐producing cells, demonstrated significant joint efficacy and inhibition of structural damage progression in participants with active and erosive PsA through Week (W)24; W48 findings are reported herein. Methods The APEX modified full analysis set included 1020 biologic‐
Christopher T. Ritchlin   +12 more
wiley   +1 more source

Patellar Tendon Imbrication With a Double‐Row Configuration for the Treatment of Patella Alta in Skeletally Immature Patients

open access: yesArthroscopy Techniques, EarlyView.
Abstract Patella alta is a major anatomical risk factor for patellar instability. Although a tibial tubercle osteotomy with distalization has been described in this context, a patellar tendon imbrication more directly addresses the pathoanatomy and avoids the risk of physeal and apophyseal injury in skeletally immature patients.
Mauricio Drummond Jr.   +6 more
wiley   +1 more source

Sternoclavicular Joint Reconstruction for Chronic Anterior Instability: An Updated Sternal Docking Technique With a Modified Girth Hitch

open access: yesArthroscopy Techniques, EarlyView.
Abstract Chronic anterior sternoclavicular joint instability can be functionally limiting in active patient populations, requiring reconstruction in patients who fail to achieve acceptable outcomes with nonoperative treatment. A variety of reconstruction techniques have been described including allograft or autograft figure‐of‐8 reconstruction ...
Nate J. Dickinson   +5 more
wiley   +1 more source

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