Results 251 to 260 of about 5,587,670 (347)

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

Heartburn Takes a Whole New Meaning: Multidisciplinary Management of a Gastropericardial Fistula. [PDF]

Case Rep Surg
Sypniewski J, Kelley JK, Fritz GD, Lam G, Zolotarevsky E.   +4 more
europepmc   +1 more source

Awareness of the Black Triangle Scheme among healthcare professionals and consumers in Australia: A mixed‐methods study exploring reporting intentions and suggested improvements

British Journal of Clinical Pharmacology, EarlyView.
Aims The Black Triangle Scheme, introduced in 2018 in Australia, does not appear to have increased the quantity of adverse drug event (ADE) reports. This study evaluated healthcare professionals' (HCPs') and consumers' awareness of the scheme, its influence on intentions for future ADE reporting, and suggested improvements.
Eyob Alemayehu Gebreyohannes, Sieta T. de Vries, Mohammed Gebre Dedefo, Oliver Frank, Myra Thiessen, Lisa Kalisch Ellett, Christopher Thornton, Renly Lim   +7 more
wiley   +1 more source

Axial Torsion of a Necrotic Giant Meckel's Diverticulum With Secondary Peritonitis in a 7-Year-Old: A Case Report. [PDF]

Case Rep Surg
Trăilescu MD, Pavel AI, Crișan AS, Cindea CN, Osakwe HI, Boștinaru GM.   +5 more
europepmc   +1 more source

Does Climate Risk Affect Employment Decisions? International Evidence

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates the effect of climate risk on corporate employment decisions. Using a large sample from 41 countries, we find a positive association between climate risk and underinvestment in labor, notably manifesting as excessive employee layoffs.
Claude Francoeur, Faten Lakhal, Hamza Nizar, Zvi Singer   +3 more
wiley   +1 more source

A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance. [PDF]

Proc Natl Acad Sci U S A
Liaki V, Barrambana S, Kostopoulou M, Lechuga CG, Zamorano-Dominguez E, Acosta-Gallego D, Morales-Cacho L, Álvarez R, Sun P, Rosas-Perez B, Barrero R, Jiménez-Parrado S, López-García A, San Roman M, López-Gil JC, Drosten M, Sainz B, Musteanu M, Caleiras E, Dusetti N, Poli V, Sánchez-Bueno F, Guerra C, Barbacid M.   +23 more
europepmc   +1 more source

Can Private Equity Deliver on Its Societal Ambitions? What We Know and Don't Know About Environmental, Social, and Governance Factor Integration in Private Equity

Business Strategy and the Environment, EarlyView.
ABSTRACT Private equity (PE) firms increasingly integrate environmental, social, and governance (ESG) factors in investment decisions and raise impact funds to address sustainability challenges. We review and integrate the growing body of literature on why, when, and how PE fund managers incorporate ESG factors into their investment strategies and ...
Tjarda Molenaar, Christopher Wickert, Svetlana Khapova   +2 more
wiley   +1 more source

Diagnostic sequence of chronic pain and severe mental illness: Relationship with mental health and hospitalization outcomes. [PDF]

Br J Pain
Ma R, Romano E, Ashworth M, Mossaheb N, Böge K, Vancampfort D, Stewart R, Stubbs B.   +7 more
europepmc   +1 more source

Applying the Rules of Evidence to Expert Testimony About Risk

Behavioral Sciences &the Law, EarlyView.
ABSTRACT Expert opinion about dangerousness or risk is common at sentencing, criminal commitment proceedings and some types of pretrial detention hearings. This article argues that such evidence must be (1) “material” (logically relevant, empirically generalizable, and epistemologically germane), (2) “probative” (a measure of accuracy, which is ...
Christopher Slobogin
wiley   +1 more source

Laparoscopic Management of Small Bowel Obstruction and Ischemia Caused by Spontaneous Transomental Hernia in a Virgin Abdomen: A Case Report. [PDF]

Case Rep Surg
Mousli A.
europepmc   +1 more source