Results 51 to 60 of about 5,587,670 (347)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ammonia measurements from space with the Cross-track Infrared Sounder (CrIS): characteristics and applications

Atmospheric Chemistry and Physics, 2019
Satellite data are helping to fill monitoring gaps in order to better inform decision makers and assess the impact of ammonia-related policies.  Presented is an overview demonstrating the current capabilities of the ammonia (NH3) data product ...
M. Shephard, C. McLinden, E. Dammers, S. Kharol, K. Cady-Pereira, Junhua Zhang, S. Bittman, E. Chow, E. White   +8 more
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

MERCOSUR versus Chronic non-communicable diseases (NCD)

Revista MERCOSUR de Políticas Sociales, 2018
Chronic non-communicable diseases (NCDs) constitutes a global challenge. A coordinated answer to address NCD includes the articulation of policies forward the Health sector and the role of the State, in conjunction with private sector and civil society ...
Sebastian Tobar, Paulo Marchiori Buss
doaj   +1 more source

Radiometrically Consistent Climate Fingerprinting Using CrIS and AIRS Hyperspectral Observations

Remote Sensing, 2020
We introduce a novel spectral fingerprinting scheme that can be used to derive long-term atmospheric temperature and water vapor anomalies from hyperspectral infrared sounders such as Cross-track Infrared Sounder (CrIS) and Atmospheric Infrared Sounder ...
Wan Wu, Xu Liu, Qiguang Yang, Daniel K. Zhou, A. Larar   +4 more
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Bibliometric Approach for Department-Level Disciplinary Analysis and Science Mapping of Research Output Using Multiple Classification Schemes

Journal of Contemporary Eastern Asia, 2019
This study describes an approach for comparative bibliometric analysis of scientific publications related to (i) individual or several departments comprising a university, and (ii) broader integrated subject areas using multiple disciplinary schemes.
Gautam, Pitambar
doaj   +1 more source

PLAYING WITH THE CRIES

Samuel Beckett Today / Aujourd'hui, 1997
Clues provided by the text suggest that we should read Beckett's "First Love" in an associative way, and attending to its repetitive structure. The narrative has been organized as a working out of variations on the themes of death, marriage, and birth.
openaire   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Meta-participation in multistakeholder mechanisms: Peruvian civil society and the free trade agreement with the EU

European Review of Latin American and Caribbean Studies, 2023
This paper elaborates on the relatively unknown concept of meta-participation: stakeholders’ attempts to reorganize the way in which their participation in decision-making is organized.
Diana Potjomkina
doaj   +1 more source