Results 181 to 190 of about 1,168,879 (292)

Sickle cell related cardiomyopathy and cardiovascular autonomic dysfunction. [PDF]

Front Cardiovasc Med
Hartnett J, Connolly N, Quinn S, Murphy R, Tuohy E, Curtain J, Mogensen J, Kenny RA, Maree AO.   +8 more
europepmc   +1 more source

Crise urbaine, crise sociale, crise des polices ?

Systèmes policiers Européens XVIIIe-XIXe siècle, 2012
openaire   +1 more source

Fiscal crises [PDF]

Journal of International Money and Finance, 2017
Paulo Medas, Tigran Poghosyan, Yizhi Xu, Juan Farah-Yacoub, Kerstin Gerling   +4 more
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Une crise agricole mais quelle crise ?

L’article analyse les crises agricoles en soulignant leur spécificité : au-delà des mécanismes économiques classiques, elles touchent à la sécurité et à la souveraineté alimentaires, pouvant provoquer des tensions sociales et politiques. Elles résultent d’aléas climatiques, de maladies, de fluctuations des prix mondiaux, de la hausse des intrants ou de
openaire   +4 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Strengthening and sustaining gender-based violence (GBV) coordination in emergencies: a synthesis of practitioner-driven, globally applicable recommendations. [PDF]

Confl Health
Raftery P, Potts A, Hyde M, Wuyke YY, Hashmey H, Munezero L, Kiss L, Hossain M, Palmer J.   +8 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Global health in the face of 'permacrises': why primary health care matters. [PDF]

Prim Health Care Res Dev
Omam LA, Nkengateh AN, Mba CM.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source