Results 161 to 170 of about 4,296,035 (305)

What Crisis? Competing Narratives of Mental Health in US Higher Education. [PDF]

Cult Med Psychiatry
Raikhel E.
europepmc   +1 more source

Nepal's Fragile Peace Process [PDF]

, 2007
International Crisis Group
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Research progress in flap temperature monitoring technologies and applications after transplantation. [PDF]

APL Bioeng
Hu T, Yan T, Chen J, Huang Q, Cui M, Han Y, Li K.   +6 more
europepmc   +1 more source

Nepal's Future: In Whose Hands? [PDF]

, 2009
International Crisis Group
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Operating in recurrent crises: a qualitative study of decision-making and unintended consequences in a peripheral hospital. [PDF]

Front Public Health
Bernstine T, Edelstein M, Spitzer S.
europepmc   +1 more source

Nepal: Responding to the Royal Coup [PDF]

, 2005
International Crisis Group
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Telomere Crisis Shapes Cancer Evolution. [PDF]

Cold Spring Harb Perspect Biol
Nassour J, Karlseder J.
europepmc   +1 more source