Results 191 to 200 of about 1,333,946 (313)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A case of Nelson's syndrome with adrenal crisis occurring 21 years post-adrenalectomy for Cushing's disease. [PDF]

BMC Endocr Disord
Wang M, Xu Y, Dong Z, Song Y.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Governing Iraq / International Crisis Group

, 2003
unknown
core   +1 more source

Acute neurologic crisis after bronchoscopic biopsy: Carcinoid-like presentation of pulmonary mucoepidermoid carcinoma. [PDF]

Respir Med Case Rep
Bitar A, Tayar E, Dahdel M.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Sudan endgame / International Crisis Group

, 2003
unknown
core   +1 more source

Using Digital Mental Health and Measurement-Based Care With Youth Experiencing Suicidal Thoughts and Behaviors: Qualitative Study of Clinician Barriers and Facilitators. [PDF]

JMIR Hum Factors
Norman L, Bright K, Pintson K, Hews-Girard J, D'Silva A, Habina C, Pricop DF, Henry G, Daniel S, Volcko L, Greer K, Gondziola J, Stamp L, Fersovitch M, Moskovic K, Bradley J, LaMonica HM, Hickie I, Iorfino F, Johnson D, Arnold P, Dimitropoulos G.   +21 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Extreme makeover? / International Crisis Group

, 2013
unknown
core   +1 more source