Results 241 to 250 of about 5,358,439 (388)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An Age of Crisis: Man and World in Eighteenth-Century French Thought [PDF]

, 1960
Leland Thielemann, Lester G. Crocker
openalex   +2 more sources

Enabling informed decisions for climate risk and crisis management. The BRACE review protocol. [PDF]

MethodsX
Michetti M, D'Angelo A.
europepmc   +1 more source

The Crisis in Crisis Standards of Care

Annals of the American Thoracic Society, 2021
openaire   +3 more sources

Nepal's Fragile Peace Process [PDF]

, 2007
International Crisis Group
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Qualitative Description Study of the Patient's Experience With Community-Based Virtual Crisis Care in Canada: Illustrating the Potential Positives and Negatives of Remote Support on Recovery. [PDF]

J Patient Exp
Buchel A, Lemoine J, Bolton JM, Hensel JM.   +3 more
europepmc   +1 more source

A Global Crisis for Seagrass Ecosystems

, 2006
R. Orth, Timothy J.B. Carruthers, W. Dennison, Carlos M. Duarte, J. Fourqurean, K. L. Heck, A. Hughes, G. Kendrick, W. Kenworthy, S. Olyarnik, Frederick T. Short, M. Waycott, Susan L. Williams, R. Orth   +13 more
semanticscholar   +1 more source

Nepal's Maoists: Purists or Pragmatists? [PDF]

, 2007
International Crisis Group
core  

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source