Results 281 to 290 of about 5,358,439 (388)

Opioid Crisis: No Easy Fix to Its Social and Economic Determinants.

American Journal of Public Health, 2018
N. Dasgupta, L. Beletsky, D. Ciccarone
semanticscholar   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

La crisis universitaria, por Ernst Curtius, C. Bouglé y otros

, 1933
Revista Atenea
openalex   +2 more sources

A trans-disciplinary approach to assessing police responses to mental heath crisis: development of the de-escalating persons in crisis competencies tool (DePICT). [PDF]

Front Psychol
Lavoie JAA, Álvarez N, Martin K, Girard M, Coleman TG.   +4 more
europepmc   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Constitutional crisis in India

, 1937

openalex   +2 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

'A community in crisis': staff qualitative experiences of NHS and third sector mental healthcare in England. [PDF]

BJPsych Open
Sambrook L, McIntyre JC, Nathan R, Tait J, Ashley-Mudie P, Humphreys M, Wilson P, Saini P.   +7 more
europepmc   +1 more source

Cervical cancer: A global health crisis

Cancer, 2017
W. Small, M. Bacon, A. Bajaj, L. Chuang, B. Fisher, M. Harkenrider, A. Jhingran, H. Kitchener, L. Mileshkin, A. Viswanathan, D. Gaffney   +10 more
semanticscholar   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source