Results 71 to 80 of about 6,226,749 (260)

Global Health Crisis, Global Health Response: How Global Health Experiences Prepared North American Physicians for the COVID-19 Pandemic. [PDF]

open access: yesJ Gen Intern Med, 2022
Coria AL   +6 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

East Asia and the global/transatlantic/Western crisis [PDF]

open access: yes, 2011
This paper introduces the special collection on East Asia and the Global Crisis. After justifying why a focus on East Asia is appropriate, it draws out the main themes that run through the individual contributions.
Breslin, Shaun, Shaun Breslin
core   +1 more source

Ábel az interneten

open access: yesSymbolon, 2020
Ábel on the Internet The paper enumerates the changes threatening the world stemming from the increase of volatility, uncertainty, complexity, and ambiguity.
György Csepeli
doaj  

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Una salida territorial a la crisis: Lecciones de la experiencia latinoAméricana

open access: yesEURE (Santiago) - Revista Latinoamericana de Estudios Urbano Regionales, 2009
Las economías avanzadas y emergentes se han visto afectadas por la crisis del sistema financiero que dificulta el funcionamiento de la economía real. Por ello la respuesta a la crisis ha de combinar medidas cuyo objetivo es recuperar la confianza en el ...
ANTONIO VÁZQUEZ BARQUERO
doaj  

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Rape Crisis Centre 2002 statistics and financial summary.

open access: yes, 2003
I have audited the financial statements above and opposite in accordance with Auditing Standards. In my opinion, the financial statements give a true and fair view of the statement of the company's affairs at 31 st December 2002, and of its results ...
Rape Crisis Centre.
core  

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