Results 141 to 150 of about 270,386 (291)
Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare
Advanced Robotics Research, EarlyView.Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin +3 more
wiley +1 more source
Ciencia Política, 2017 Diversos debates se han tejido en Nuestra América sobre los impactos de la crisis capitalista del último tiempo y la necesidad imperativa de construir alternativas que permitan resolver los asuntos fundamentales que de ella se desprenden.
Carolina Jiménez, Napoleón Saltos
doaj
ELABELA Targets Mitochondria to Modulate Heart Development
Advanced Science, EarlyView.The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang +22 more
wiley +1 more source
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Measuring inequality of well-being with a correlation-sensitive multidimensional Gini index [PDF]
We propose to measure inequality of well-being with a multidimensional generalization of the Gini coefficient. We derive two inequality indices from their underlying social evaluation functions.
Koen Decancq, María Ana Lugo
core
MULTIDIMENSIONAL MODEL OF THE STRUCTURE OF READINESS FOR MOTHERHOOD IN CRISIS SITUATIONS
"Scientific notes of the University"KROK"The article presents a theoretical analysis of psychological readiness for motherhood concepts developed by Ukrainian researchers over the past 15 years. The relevance of this study is determined by contemporary social challenges, particularly the impact of war and crisis situations on women's psychological well-being and their readiness for motherhood.
openaire +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Comparing Human Development Patterns Across Countries: Is it Possible to Reconcile Multidimensional Measures and Intuitive Appeal? [PDF]
The aims of this paper are two. The first is to to present a framework that facilitates the identification and analysis of human development patterns in terms of outcomes performance from a cross and time perspective.
Mario Biggeri, Vincenzo Mauro
core
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source