Results 191 to 200 of about 266,944 (280)

End points for sickle cell disease clinical trials: Patient-reported outcomes, pain, and the brain [PDF]

, 2019
al., et, Farrell, Ann T., King, Allison A.   +2 more
core   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

Development and validation of the concise midlife crisis measure. [PDF]

Sci Rep
Husain W, Trabelsi K, Ali A, Usman Y, Husain MA, Ijaz F, Ammar A, Jahrami H.   +7 more
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Impact of school support on cognitive engagement strategies in crisis contexts: dual pathways of academic motivation and psychological resilience. [PDF]

Front Psychol
Wang M, Xiong Y, Wang M.
europepmc   +1 more source

Beyond Sabatier: Multiplicate Spillover Phenomena for Manipulating Catalytic Dynamics in Various Electrocatalysis

Advanced Science, EarlyView.
Various spillover‐mediated electrocatalytic reactions, such as hydrogen and oxygen evolution, carbon dioxide and nitrogen reduction, and methanol oxidization reactions, are systematically summarized. Abstract Spillover phenomenon, which is characterized by the dynamic migration of active species across catalyst surfaces, provides a promising avenue to ...
Di Wang, Ziyou Dong, Qianqian Yao, Shixue Dou, Jun Mei, Ziqi Sun   +5 more
wiley   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

COVID-19 mortality associated with multidimensional poverty, ethnicities, and armed conflict in Colombia: retrospective observational study based on national records. [PDF]

Front Public Health
Birchenall-Jiménez CI, Jiménez-Barbosa WG, Riascos-Ochoa J, Cosenz F.   +3 more
europepmc   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Mapping the multifaceted resilience construct: a facet-based approach. [PDF]

Front Psychol
Shwartz-Asher D, Tziner A.
europepmc   +1 more source