Results 111 to 120 of about 19,765 (302)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Mapping Common Ground : Ecocriticism, Environmental History, and the Environmental Humanities

, 2014
The emergence of the environmental humanities presents a unique opportunity for scholarship to tackle the human dimensions of the environmental crisis.
Kneitz, Agnes, Bergthaller, Hannes, Lidström, Susanna,, Emmett, Rob, McCorristine, Shane, Johns-Putra, Adeline, Pérez Ramos, Isabel,, Phillips, Dana, Rigby, Kate, Robin, Libby,   +9 more
core  

Mapping Common Ground: Ecocriticism, Environmental History, and the Environmental Humanities

, 2019
The emergence of the environmental humanities presents a unique opportunity for scholarship to tackle the human dimensions of the environmental crisis.
Johns-Putra, Adeline, McCorristine, S, Emmett, R, Ramos, IP, Bergthaller, H, Lidstrom, S, Robin, L, Kneitz, A, Phillips, D, Rigby, K   +9 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The Crisis of Human Rights Discourse

PRAWO i WIĘŹ
Although the “crisis” of human rights discourse has many aspects, it is hard not to get the impression that the most important of them is the incorrect understanding of the philosophical foundations of these rights. The paper presents various hypotheses regarding the nature of this error. The first hypothesis suggests that this crisis simply stems from
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Planlös forskning?

Lychnos, 2019
Already in the 1960s, internationalisation was seen as a pressing concern for the humanities as Sweden, among other Western European countries, saw an increased interest in research policy in the context of the technological hype of the Cold War ...
Hampus Östh Gustafsson
doaj  

The Sounds of Silence: Perspectives on Documenting Acoustic Landscapes at the Intersection of Remoteness, Conservation and Tourism

Humanities
The humanities are often criticised for lacking a way through from the complexity they reveal to the challenges they might hope to address. In the face of the accelerating biodiversity crisis, we present two projects that aim to respond to the ...
Jonathan Carruthers-Jones, George Holmes, Roger Norum   +2 more
doaj   +1 more source

Subprime Crisis: American Crisis or Human Crisis? [PDF]

Environment and Planning D: Society and Space, 2008
openaire   +1 more source