Results 51 to 60 of about 229,715 (264)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Journal of Rock Mechanics and Geotechnical Engineering, 2019 Reliability-based design (RBD) is being adopted by geotechnical design codes worldwide, and it is therefore necessary that rock engineering practice evolves to embrace RBD.
Nezam Bozorgzadeh, John P. Harrison
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Rock strength criterion considering the effect of hydrostatic stress on lode angle effect
Energy Science & Engineering, 2019 Rock strength criterion is a basic subject in mining engineering and petroleum engineering. It has important guiding significances to the process of underground energy exploitation. Different rocks have different strength envelopes.
Zhenlong Song +4 more
doaj +1 more source
Failure criteria for C/SiC composites under plane stress state
Theoretical and Applied Mechanics Letters, 2014 The applicability and limitation of several quadratic strength theories were investigated with respect to 2D-C/SiC and 2.5D-C/SiC composites. A kind of damage-based failure criterion, referred to as D-criterion, is proposed for nonlinear ceramic ...
Chengpeng Yang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Strength behaviour of sandstone subjected to polyaxial state of stress
International Journal of Mining Science and Technology, 2017 The paper presents an experimental investigation on the strength behaviour of natural rock subjected to polyaxial state of stress. The polyaxial tests were conducted on cubical specimens of sandstone obtained from the Shivpuri district in Madhya Pradesh ...
Saurav Rukhaiyar +1 more
doaj +1 more source
Wellbore stability analysis of layered shale based on the modified Mogi–Coulomb criterion
Petroleum, 2020 Borehole instability was frequently encountered during shale gas drilling. Most conventional models are not applicable to layered formation's wellbore stability analysis on account of anisotropic strength characteristic.
Xu Yang +3 more
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source