Results 11 to 20 of about 2,160 (176)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles, Hannah F. Brubeck, Adrienne D. Tanus, Courtney N. Loecker, Punyasha Roul, Bryant R. England, Elizabeth R. Wahl, James S. Andrews, Namrata Singh, Joshua F. Baker, Patricia P. Katz, Dolores M. Shoback, Jose M. Garcia, Ariela R. Orkaby, Katherine D. Wysham   +14 more
wiley   +1 more source

Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up

Arthritis Care &Research, EarlyView.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source

The Association of Physical Function With Psychosocial Patient‐Reported Outcomes in People With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective To evaluate how modifiable psychosocial factors and fatigue relate to physical functioning in patients with systemic lupus erythematosus (SLE). Methods In this cross‐sectional study of two demographically distinct cohorts (Approaches to Positive, Patient‐Centered Experiences of Aging with Lupus [APPEAL] and California Lupus Epidemiology Study
Mrinalini Dey, Jessica Fitzpatrick, Maria Dall'Era, Charmayne Dunlop‐Thomas, Courtney Hoge, S. Sam Lim, Patricia P. Katz, Jinoos Yazdany, Laura C. Plantinga   +8 more
wiley   +1 more source

Halide Perovskite Integrated Photovoltaic Cathodes Incorporating Pt on ZIF‐8‐Derived Carbon for Solar Hydrogen Production

Advanced Functional Materials, EarlyView.
A low‐Pt catalyst supported on zeolitic imidazolate framework (ZIF‐8)‐derived porous carbon and graphite is integrated with a halide perovskite photovoltaic, yielding cathodes that achieve a high photocurrent density (∼20 mA cm−2) under simulated sunlight and exhibit remarkable stability in acidic media over several days, thereby demonstrating a ...
Na Yeong Oh, Woo Jin Mun, Kamran Dastafkan, Matyas Daboczi, Hongki Kim, Humza Bhatti, Eunyoung Hong, Minzhi Chen, Yongqi Huang, Jin Hyuk Kim, Nicola Gasparini, Jong Hak Kim, Salvador Eslava   +12 more
wiley   +1 more source

Portable Molecularly Imprinted Polymer Sensor for Rapid Swab‐Based Detection of Norovirus

Advanced Healthcare Materials, EarlyView.
This work reports a rapid, portable smartphone‐based sensor capable of detecting four norovirus genotypes from swab samples within 15 min. Sensor selectivity was validated through evaluation against four common live viruses. The swab‐based sampling process enabled simple sample preparation combined with the compact detection system, supporting use of ...
Amy Dann, Pankaj Singla, Minji Kim, Sloane Stoufer, Clare Thomas, Robert D. Crapnell, Craig E. Banks, Jake McClements, Shayan Seyedin, Mark Geoghegan, Samuel T. Jones, Christopher F. Blanford, Matthew D. Moore, Marloes Peeters   +13 more
wiley   +1 more source

Atomically Dispersed Mo–S Sites Boost NiFe–Layered Double Hydroxide for Industrial‐Level Seawater Electrolysis

Advanced Energy Materials, EarlyView.
(Mo–S)1@NiFe–LDH promotes the rapid structural transition to the active oxyhydroxide phase, enabling selective seawater oxidation at industrial‐level current densities. Atomically dispersed Mo–S sites within the LDH lattice efficaciously modulate the structural flexibility to lower the thermodynamic barrier for early‐phase activation.
Jae Kwan Lee, Jaehyun Kim, Byeong‐Gwan Cho, In‐Hui Hwang, Woo Seok Cheon, Jiheon Lim, Kiryong Hong, Hong Gi Kim, Jong Hwan Lim, Sooheyong Lee, Jong Hun Kang, Min Sang Kwon, Ki Chang Kwon, Sun Hwa Park, Ho Won Jang   +14 more
wiley   +1 more source

Ultrathin Aluminum–Air Batteries via Hygroscopic Electrolytes for Continuous Operation of Imperceptible On‐Skin Electronics

Advanced Energy Materials, EarlyView.
This study presents ultrathin, high‐capacity aluminum‐air batteries (AABs) for self‐sustaining, skin‐conformal electronics. By utilizing ambient moisture and oxygen alongside a LiCl‐based hygroscopic hydrogel electrolyte, the design significantly reduces battery thickness while preventing dehydration and Al self‐corrosion.
Jaeil Park, Inho Lee, Namhee Kim, Wonseok Shin, Joo Sung Kim, Daegun Kim, Giwon Lee, Jinhan Cho, Hoon‐Hee Ryu, Myung‐Han Yoon, Seung Joon Yoo, Woo‐Jin Song, Sungjun Park   +12 more
wiley   +1 more source

Multiscale Design of Anion Exchange Membrane‐Based Seawater Electrolysis for Sustainable Hydrogen Production

Advanced Energy Materials, EarlyView.
Direct seawater electrolysis using anion exchange membranes is emerging as a promising route for sustainable hydrogen production. This review summarizes multiscale design strategies from seawater chemistry and OER–ClER selectivity to catalysts, membranes, MEAs, cells, stacks, and system integration, providing a roadmap toward selective, durable, and ...
Chiho Kim, Geunhee Yuk, Jong‐Hyeok Park, Shin‐woo Myeong, Jun Seok Ha, Won Tae Hong, Jung Kyu Kim, Sung Mook Choi   +7 more
wiley   +1 more source