Results 51 to 60 of about 20,115 (268)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Creative vs Defective: A Critical Review of Malang Creative Center (MCC) in Malang City

RUAS
The Malang Creative Center (MCC) construction is a step taken by the Malang City government to support the flow of modernization and as a forum for Malang residents to develop their creativity. The MCC display concept is planned by combining the shape of
Bunga Pasadena Ineru, Yusfan Adeputera Yusran, Joko Triwinarto Santoso, Moch. Ardiansyah Fendy Wijaya, Susilo Kusdiwanggo   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Strategy Selection for Natural Resource Conservation Capturing Vagueness through Integrated Neutrosophic CRITIC-MAIRCA Approach [PDF]

Neutrosophic Sets and Systems
Conservation of natural resources like water, soil, and biodiversity is necessary for ecological balance and human survival. This article aims to identify potential ways to conserve natural resources while maintaining a balance between ecology and human ...
Bahnishikha Roy Muhuri, Florentin Smarandache, M.K. Mondal, G.S. Mahapatra, B.S. Mahapatra   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Optimizing Blockchain Platform Selection: A Decision-Making Approach Using LLMs, Type-2 Neutrosophic Numbers, CRITIC, and MAIRCA [PDF]

Neutrosophic Sets and Systems
Blockchain (BC) platforms integrated with Generative AI (GenAI) like Large Language Models (LLMs) are the basic infrastructure for significant consumer data like Bitcoin and Smart Contracts systems, addressing challenges such as protection from anomalous
Hend Ahmed, Abduallah Gamal, Ahmed Abdelmouty   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

¿Más participación igual a mejor democracia? Acerca de la crítica a la democracia participativa // More participation equal than better democracy? On critic to participatory democracy.

Revista de Derecho Político, 2015
Resumen, En el presente, y en países como España, la crítica a la democracia representativa tal y como ésta se concibe actualmente parece ir más allá de la recurrente reflexión sobre la crisis de la representación para alcanzar niveles de enmienda a la ...
Alfredo Ramírez Nárdiz
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source