Results 41 to 50 of about 531,090 (261)
What Does Music Mean to Spotify? An Essay on Musical Significance in the Era of Digital Curation
INSAM, 2019 The growing field of “critical algorithm studies” often addresses the cultural consequences of machine learning, but it has ignored music. The result is that we inhabit a musical culture intimately bound up with various forms of algorithmic mediation ...
Asher Tobin Chodos
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Short-time critical dynamics of the Ising model studied within the N-fold algorithm
Physica A: Statistical Mechanics and its Applications, 2003 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Malakis, A. +2 more
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Lyapunov Optimization-Based Online Positioning in UAV-Assisted Emergency Communications
IEEE Access, 2023 In disasters, unmanned aerial vehicles (UAVs) can be used as aerial base stations (BSs) when terrestrial BSs are unavailable. Although most studies have focused on optimal UAV localization to provide efficient network connectivity for outdoor users ...
Junghwa Kang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
IEEE Access, 2020 Microgrid instability poses critical issues to the power delivery following a load change or a tripping event. In island operating mode lack of grid intensifies this challenge.
Bahram Pournazarian +4 more
doaj +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Hybrid Sorting Immune Simulated Annealing Algorithm For Flexible Job Shop Scheduling [PDF]
International Journal of Computational Intelligence Systems, 2015 Hybrid sorting immune simulated annealing technique (HSISAT), a Meta - heuristic is proposed for solving the multi objective flexible job-shop scheduling problem (FJSP).
N. Shivasankaran +2 more
doaj +1 more source