Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth+2 more
wiley +1 more source
Development and validation of a prediction score for early identification of palliative care needs for patients in the intensive care unit: a multicentre retrospective cohort study. [PDF]
Tenge T+15 more
europepmc +1 more source
Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt+2 more
wiley +1 more source
Lens on eye care in intensive care units: deficiencies, training, and improvement recommendations - a descriptive observational study. [PDF]
Yıldız AT, Ceyhan Ö.
europepmc +1 more source
Recycling of Thermoplastics with Machine Learning: A Review
This review shows how machine learning is revolutionizing mechanical, chemical, and biological pathways, overcoming traditional challenges and optimizing sorting, efficiency, and quality. It provides a detailed analysis of effective feature engineering strategies and establishes a forward‐looking research agenda for a truly circular thermoplastic ...
Rodrigo Q. Albuquerque+5 more
wiley +1 more source
Echocardiography guided management of atrial fibrillation. [PDF]
Balik M+12 more
europepmc +1 more source
This work presents a soft microelectrode array based on vertically aligned carbon nanotube (CNT) forests, combining high conductivity with mechanical softness. A densification process and air‐pressure‐assisted flexibilization improve structural integrity, ensuring stable insertion and reduced inflammation.
Hyeonhee Roh+8 more
wiley +1 more source
Correction: How to approach a patient hospitalized for pneumonia who is not responding to treatment? [PDF]
Povoa P+14 more
europepmc +1 more source
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen+30 more
wiley +1 more source