Results 131 to 140 of about 2,745,548 (338)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Prognostic Value of SIRI in Sepsis: A Retrospective Study and Machine Learning-Based Model Development

Journal of Inflammation Research
Yilin Zhu,1,* Zhiyang Wang,2,* Shifeng Li,3,* Xin Xiao,3 Yujie Liu,3 Jiachen He,3 Fang Huang,3 Jun Wang3 1Department of Critical Care Medicine, Zhangjiagang Hospital Affiliated to Soochow University/The First People’s Hospital of ...
Zhu Y, Wang Z, Li S, Xiao X, Liu Y, He J, Huang F, Wang J   +7 more
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Antifreeze Poisoning Complicated by Severe Metabolic Acidosis, Toxic Encephalopathy, and Multiple Organ Dysfunction Syndrome: A Case Report

Open Access Emergency Medicine
Min Liu,1– 3 Yayuan Tan,1– 3 Yinchun Xie,1,4 Jinglan Liu,1– 3 Haishuang Mei,1– 3 Dan Jin,1– 3 Zhaohui Zhang1– 3 1Department of Intensive Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, People’s ...
Liu M, Tan Y, Xie Y, Liu J, Mei H, Jin D, Zhang Z   +6 more
doaj  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Induced Sputum Transcriptomics Profile and Serum C3 are Associated with Asthma Severity

Journal of Asthma and Allergy
Fawang Du,1,* Hanchao Wang,2,* Zhihong Chen,3,* Wei Xiong,1 Qin Wang,4 Bo Li,1 Rong Li,1 Li Li,1 Yongchun Shen,5 Tao Zhu1 1Department of Respiratory Medicine and Critical Care Medicine, Suining Central Hospital, Suining, Sichuan ...
Du F, Wang H, Chen Z, Xiong W, Wang Q, Li B, Li R, Li L, Shen Y, Zhu T   +9 more
doaj  

News in Brief [PDF]

, 2016
Matthew P. Jenkins, MD, has joined the Division of Plastic Surgery. Dr. Jenkins completed his general surgery residency at Temple University Hospital in 2013 and remained there for fellowship training in Plastic and Reconstructive Surgery.

core   +1 more source

Importance of clinical parameters for cultivation of critical care thinking by online teaching of critical care medicine [PDF]

, 2023
Pan Pan, Min Zheng, Hongbo Luo, Jinbang Liu, Lina Li, Longxiang Su   +5 more
openalex   +1 more source