Results 161 to 170 of about 2,745,548 (338)

Ketamine analgo‐sedation for mechanically ventilated critically ill adults: A rapid practice guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine [PDF]

Marwa Amer, Morten Hylander Møller, Mohammed Alshahrani, Yahya Shehabi, Yaseen M. Arabi, Fayez Alshamsi, Martin I. Sigurðsson, Marius Rehn, Michelle S. Chew, Maija‐Liisa Kalliomäki, Kimberley Lewis, Faisal Al-Suwaidan, Hasan M. Al‐Dorzi, Abdulrahman Al‐Fares, Naif Alsadoon, Carolyn M. Bell, Christine M. Groth, Rachael Parke, Sangeeta Mehta, Paul E. Wischmeyer, Awad Al‐Omari, Klaus T. Olkkola, Waleed Alhazzani   +22 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Non-Pharmacological Interventions for Emotional Symptoms in COPD Centered on Anxiety and Depression: An Evidence Synthesis Study

International Journal of COPD
Jie Yu,* Jianmei Fu,* Shujuan Zhao, Shuting Zhang, Rui Huang, Tong Li, Yulan Li Department of Respiratory and Critical Care Medicine, Hebei CNPC Central Hospital, Langfang, Hebei, People’s Republic of China*These authors ...
Yu J, Fu J, Zhao S, Zhang S, Huang R, Li T, Li Y   +6 more
doaj  

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Critical care medicine and the perioperative physician

, 1999
Michael W. Russell, C. William Hanson
openalex   +1 more source

Critical care medicine in the 21st century: from CPR to PCR. [PDF]

, 2001
Jesús Villar, Sebastián Méndez, Arthur S. Slutsky   +2 more
openalex   +1 more source

Patient Care in Emergency and Critical Care Medicine: An Interview with Dr. Robert Arntfield

, 2021
Brintha Sivajohan, Himani Dhar
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Advanced critical care practitioners – Practical experience of implementing the Advanced Critical Care Practitioner Faculty of Intensive Care Medicine Curriculum in a London Critical Care Unit: Response letter [PDF]

, 2019
Christopher Williams, Emma Bennett, Nia Bromage   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source