Results 191 to 200 of about 2,745,548 (338)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Current Perspectives on the Artificial Intelligence in Critical Care Medicine. [PDF]

Anesthesiol Clin
Lee J, Yoon JH.
europepmc   +1 more source

Administration of Kampo medicine through a tube at an advanced critical care center

, 2018
Takahiro Niimura, Yoshito Zamami, Toru Imai, Tsuyoshi Ito, Hidenori Sagara, Hiroyuki Hichiya, Satoru Esumi, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Manabu Amano, Naomi Kurata, Yoshihisa Kitamura, Hironori Nakura, Toshiaki Sendo, Keisuke Ishizawa   +15 more
openalex   +2 more sources

Intensive Care Unit Rotations and Predictors of Career Choice in Pulmonary/Critical Care Medicine: A Survey of Internal Medicine Residency Directors [PDF]

, 2018
Daniel J. Minter, S Lévy, Sowmya R. Rao, Paul F. Currier   +3 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Paroxysmal Sympathetic Hyperactivity, Volume Status, and Neurological Prognosis in Acute Brain Injury: A Prospective Cohort Analysis

International Journal of General Medicine
Rongping Chen,1,* Xin Cai,2,* Xiying Gui,2 Guoying Lin,2 Wei Du3 1Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of Critical Care Medicine ...
Chen R, Cai X, Gui X, Lin G, Du W
doaj  

Implementing Artificial Intelligence in Critical Care Medicine: a consensus of 22. [PDF]

Crit Care
Cecconi M, Greco M, Shickel B, Angus DC, Bailey H, Bignami E, Calandra T, Celi LA, Einav S, Elbers P, Ercole A, Gómez H, Gong MN, Komorowski M, Liu V, Park S, Sarwal A, Seymour CW, Zampieri FG, Taccone FS, Vincent JL, Bihorac A.   +21 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Pulmonary and Critical Care Medicine Trainees' Educational Experiences and Well-Being During the COVID-19 Pandemic. [PDF]

Adv Med Educ Pract
Murali S, Velapati SR, Kaul P, Cohen RI.
europepmc   +1 more source

European Society of Intensive Care Medicine (ESICM) 2025 clinical practice guideline on fluid therapy in adult critically ill patients: part 2—the volume of resuscitation fluids

Armand Mekontso Dessap, Fayez Alshamsi, Alessandro Belletti, Daniel De Backer, Anthony Delaney, Morten Hylander Møller, Ségolène Gendreau, Glenn Hernández, Flávia Ribeiro Machado, Mervyn Mer, Manuel Ignacio Monge García, Sheila Nainan Myatra, Zhiyong Peng, Anders Perner, Michael R. Pinsky, Sameer Sharif, Jean–Louis Teboul, Antoine Vieillard‐Baron, Waleed Alhazzani, the European Society of Intensive Care Medicine, Daniel De Backer, Morten Hylander Møller, Yaseen M. Arabi, Fayez Alshamsi, Emilie Belley-Cote, Andrea Carsetti, Alessandro Protti, Katia Donadello, Nicole Juffermans, Naomi Hammond, Jon Henrik Laake, Dawei Liu, Kathryn Maitland, Antonio Messina, Rob Mac Sweeney, Jean-Louis Vincent, Fernando Zampieri, Daniele Poole, Armand Mekontso-Dessap, Waleed Alhazzani, Fayez Alshamsi, Alessandro Belletti, Anthony Delaney, Glen Hernandez, Flavia R. Machado, Manuel Ignacio Monge García, Mervin Mer, Sheila Nainan Myatra, Michael R. Pinsky, Anders Perner, Zhiyong Peng, Sameer Sharif, Jean-Louis Teboul, Antoine Vieillard-Baron, Ségolène Gendreau, Marlies Osterman, Antonio Artigas Raventós, Ichai Carole, Maurizio Cecconi, Christina Jones, Xavier Monnet, Manu Malbrain, Marek Nalos, Zhiyong Peng, Carmen Pfortmueller, John Prowle, Otavio Ranzani, Manu Shankar-Hari Adrian Wong, Carl Thomas Anthon, Anders Granholm   +69 more
openalex   +2 more sources