Results 51 to 60 of about 786,868 (262)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Effect of tailwater depth on local scour downstream of horizontal jets [PDF]
علوم و مهندسی آبیاری, 2010 In this paper the results of an experimental study on the effect of tailwater depth on the mechanism of scouring downstream of hydraulic jumps is presented.
Mohammad Hosain Omid +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Portable penetrometer for agricultural soil: sensitivity test to identify critical compaction depth
Revista Brasileira de Ciência do Solo, 2010 To express the negative effects of soil compaction, some researchers use critical values for soil mechanical strength that severely impair plant growth. The aim of this study was to identify this critical compaction depth, to test the functionality of a ...
João Carlos Medeiros +2 more
doaj +1 more source
In-depth pharmacological and nutritional properties of bael (Aegle marmelos): A critical review
Journal of Agriculture and Food Research, 2020 Aegle marmelos or bael has been known from prehistoric times in India with mythological importance. Each part of the tree like root, bark, fruit, leaf, and flower has therapeutic significance in Ayurvedic as well as other traditional medicinal systems in
Tanmay Sarkar +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Critical depth of normal cracks in reinforced concrete beams of rectangular cross-section
Journal of Civil Engineering and Management, 2013 The evaluation of stress state of longitudinal tensile reinforcement is highly important while examining the technical state of under-reinforced concrete structures. The appearance of yield stress in tensile reinforcement could be treated as the start of
Vidmantas Jokūbaitis +1 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source