Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
"Unlikely Triumph"? A Critical Discourse Analysis of Press Coverage of Teach for America
, 2012 Eric K. Nicholas Ardinger (8000009)
openalex
Applying Critical Discourse Analysis to Cross-Cultural Mental Health Recovery Research. [PDF]
JMIR Form ResKotera Y +17 more
europepmc +1 more source
Contrasting semantic and sentimental features between Chinese and American economic news discourse in the epidemic era: A corpus-based critical discourse analysis. [PDF]
Soc Sci Humanit Open, 2023 Li L, Gao F.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Correction: Media representations of China's inclusive education: A corpus-assisted critical discourse analysis. [PDF]
PLoS OneYu Y, Lu G, Sin KF, Yu Z.
europepmc +1 more source
Migrants as 'vulnerable groups' in the COVID-19 pandemic: A critical discourse analysis of a taken-for-granted label in academic literature. [PDF]
SSM Qual Res Health, 2022 Molenaar J, Van Praag L.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Critical discourse analysis of social media advertisements for GLP-1 receptor agonist weight loss drugs: implications for public perceptions and health communication. [PDF]
BMC Public HealthRad J, Melendez-Torres GJ.
europepmc +1 more source
How the Suboxone Education Programme presented as a solution to risks in the Canadian opioid crisis: a critical discourse analysis. [PDF]
BMJ Open, 2022 Sud A +6 more
europepmc +1 more source