Results 151 to 160 of about 32,031 (301)

Deploying and Examining Beacon for At-Home Patient Self-Monitoring with Critical Flicker Frequency. [PDF]

Proc SIGCHI Conf Hum Factor Comput Syst
Li R, Vutien P, Omer S, Yacoub M, Ioannou G, Karkar R, Munson SA, Fogarty J.   +7 more
europepmc   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Membrane‐Mediated Force Transduction Drives Stick‐Slip Motion of Lipid Vesicles

Advanced Science, EarlyView.
A rotating magnetic field actuates a ferromagnetic particle inside a lipid vesicle, generating internal flows that induce stick‐slip propulsion near a surface. Membrane properties—elasticity, excess area, and phase behavior—modulate this motion by shaping stress dissipation and force transduction.
Paula Magrinya, Arin Escobar Ortiz, Juan L. Aragones, Laura R. Arriaga   +3 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Investigating neurovascular responses of the peripapillary retinal artery to focal flicker stimulation of temporal retinal neurons in the living human eye using AO-OCT. [PDF]

Biomed Opt Express
Arrashoud A, Nemeth M, Kurokawa K.
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Temporal visual processing deficits in post concussion syndrome. [PDF]

Sci Rep
Frattini D, Benassi M, Wibble T, Nilsson M, Bolzani R, Pansell T.   +5 more
europepmc   +1 more source

Mitigating Electrochemical Isolation in Ni‐Rich Layered Cathodes for Durable Solid‐State Batteries

Advanced Science, EarlyView.
Electrochemical isolation of Ni‐rich layered cathodes in sulfide solid‐state batteries is uncovered as a previously unrecognized but critical performance‐limiting pathway. This study elucidates its origin and impact and introduces a scalable mitigation strategy using oxygen‐functionalized conductive carbon.
Abhirup Bhadra, Maxime Brunisholz, Aditya Rawal, Jacob Otabil Bonsu, Tongjun Luo, Lars Thomsen, Wesley M. Dose, Dipan Kundu   +7 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source