Results 171 to 180 of about 32,031 (301)

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Chronic 40 Hz light flicker mitigates epileptogenesis through a visual pathway associated with the dorsal lateral geniculate nucleus shell. [PDF]

Nat Commun
Wang L, Xu W, Wang K, Yang J, Li H, Wang Q, Dong Z, Zhang X, Meng Q, Lu F, Lei J, Yang Y, Wang K, Feng L, Wang Y.   +14 more
europepmc   +1 more source

Beyond Transconductance: Cell‐Polymer Coupling Determines Fidelity in Action Potential Recording via Electrolyte‐Gated Polymer Transistors

Advanced Science, EarlyView.
High electrical performance alone does not guarantee efficient bioelectronic signal transduction. Despite excellent mixed ionic‐electronic conduction, recordings from cardiomyocytes reveal that p(g2T‐TT)‐based OECTs predominantly transduce field potential FP‐like signals due to weak cell‐polymer coupling.
Giulia Zoe Zemignani, Elena Mancinelli, Gabriele Tullii, Aleksandr Khudiakov, Cristiano Bortolotti, Shubham Tanwar, Peter J. Schwartz, Luca Sala, Maria Rosa Antognazza, Mario Caironi, Adrica Kyndiah   +10 more
wiley   +1 more source

Scrambling‐Enhanced Quantum Battery Charging in Black Hole Analogues

Advanced Science, EarlyView.
By employing a black‐hole‐analog quantum battery constructed from a position‐dependent XY model, its dynamical behavior is investigated through a quench of the scrambling parameter. It is systematically quantified that how the simulated scrambling improves key performance metrics‐namely, stored energy, peak power, and charging time‐thereby offering a ...
Zhilong Liu, Ying Li, Zehua Tian, Jieci Wang   +3 more
wiley   +1 more source

Skin‐Inspired Design of Self‐Healing Coatings Integrating Interface‐Liquid Repellency and Corrosion Resistance

Advanced Science, EarlyView.
A skin‐inspired multilayered coating system is developed to integrate multiple, often conflicting, functions of self‐healing capability, strong liquid repellency, long‐term corrosion resistance, and robust adhesion, to tackle diverse challenges in engineering services.
Bingzhi Li, Bingce Liu, Enyu Guo, Zhihao Zhou, Yibo Ouyang, Xiao‐Bo Chen, Huijun Kang, Zongning Chen, Tongmin Wang   +8 more
wiley   +1 more source

An EAAT2b/SLC1A2b-mediated chloride leak current enables rapid cone photoreceptor signalling. [PDF]

Open Biol
Zang J, Niklaus S, Neuhauss SCF.
europepmc   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Triggered Migraine Attack by Flickering Fluorescent Lights in an Assembly Line Worker: A Case Report. [PDF]

Cureus
Gassull A.
europepmc   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source