Results 141 to 150 of about 24,963,787 (378)

An ovine septic shock model of live bacterial infusion

Intensive Care Medicine Experimental
Background Escherichia coli is the most common cause of human bloodstream infections and bacterial sepsis/septic shock. However, translation of preclinical septic shock resuscitative therapies remains limited mainly due to low-fidelity of available ...
Nchafatso G. Obonyo, Sainath Raman, Jacky Y. Suen, Kate M. Peters, Minh-Duy Phan, Margaret R. Passmore, Mahe Bouquet, Emily S. Wilson, Kieran Hyslop, Chiara Palmieri, Nicole White, Kei Sato, Samia M. Farah, Lucia Gandini, Keibun Liu, Gabriele Fior, Silver Heinsar, Shinichi Ijuin, Sun Kyun Ro, Gabriella Abbate, Carmen Ainola, Noriko Sato, Brooke Lundon, Sofia Portatadino, Reema H. Rachakonda, Bailey Schneider, Amanda Harley, Louise E. See Hoe, Mark A. Schembri, Gianluigi Li Bassi, John F. Fraser   +30 more
doaj   +1 more source

critical group

Citation: 'critical group' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15609 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial
openaire   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Early peripheral perfusion monitoring in septic shock

European Journal of Medical Research
Septic shock is a frequent critical clinical condition and a leading cause of death in critically ill individuals. However, it is challenging to identify affected patients early.
Qirui Guo, Dawei Liu, Xiaoting Wang, Chinese Critical Ultrasound Study Group (CCUSG)   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Statistics of Statisticians: Critical Masses for Research Groups [PDF]

, 2012
Ralph Kenna, Bertrand Berche
openalex   +1 more source

Critical dilution curves for calcium, magnesium, and sulfur in potato (Solanum tuberosum L. Group Andigenum) cultivars Diacol Capiro and Pastusa Suprema

, 2022
Kristal Castellanos Ruiz, Manuel Iván Gómez, Luis Ernesto Rodríguez   +2 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

An appraisal of lung computer tomography in very early anti-inflammatory treatment of two different ovine ARDS phenotypes

Scientific Reports
Mortality and morbidity of Acute Respiratory Distress Syndrome (ARDS) are largely unaltered. A possible new approach to treatment of ARDS is offered by the discovery of inflammatory subphenotypes.
Karin Wildi, Sebastiano Maria Colombo, Daniel McGuire, Carmen Ainola, Silver Heinsar, Noriko Sato, Kei Sato, Keibun Liu, Mahé Bouquet, Emily Wilson, Margaret Passmore, Kieran Hyslop, Samantha Livingstone, Marianna Di Feliciantonio, Wendy Strugnell, Chiara Palmieri, Jacky Suen, Gianluigi Li Bassi, John Fraser   +18 more
doaj   +1 more source