Results 101 to 110 of about 388,085 (306)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

An experimental study on characteristics of post-CHF heat transfer in the high subcritical pressure region near to the critical pressure

Journal of Thermal Science and Technology, 2016
Supercritical pressurized water cooled reactor (SCWR), which has a once-through water cooled reactor for supplying supercritical pressure steam at high temperature to a turbine system, is one of the next generation reactors for the purpose of improving ...
Takashi MAWATARI, Hideo MORI
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Experimental Study on Influence of External Pressure Vessel Cooling Parameters on Critical Heat Flux

Yuanzineng kexue jishu
In-vessel retention (IVR) of molten material, as one of the most important mitigation measures for serious accidents, can effectively prevent the leakage of molten material from the core to the outside of the pressure vessel, resulting in the release of ...
ZHANG Zhen1, 2, XIONG Wanyu2, XING Dianchuan2, ZAN Yuanfeng2, WANG Guangjin2, CHEN Deqi1, 3, , XU Jianjun2
doaj   +1 more source

Problem of critical area of heat transfer and energy motion under liquid binary mixtures boiling

Advanced Engineering Research, 2016
The experimental results of the heat flux critical density studying under the unsaturated boiling of the binary mixtures of water-n-butanol and water n-pentanol within the concentrations from 0 to 100% by weight of the organic component are provided. The
Evgeny V. Lykov, Victor V. Romanov, Elena S. Zhelonkina   +2 more
doaj   +1 more source

Onsager Loop-Transition and First Order Flux-Line Lattice Melting in High-$T_c$ Superconductors

, 1997
Monte-Carlo simulations in conjunction with finite-size scaling analysis are used to investigate the $(H,T)$-phase diagram in uniaxial anisotropic high- $T_c$ superconductors, both in zero magnetic field and in intermediate magnetic fields for various ...
A. Houghton, A. Junod, A. K. Nguyen, A. K. Nguyen, A. P. Young, A. Schilling, A. Schilling, A. Sudbø, A. Sudbø, A. Sudbø, A. Sudbø, B. Chattopadhyay, B. Horovitz, C. Dasgupta, D. R. Nelson, D. R. Nelson, D. R. Nelson, D. R. Nelson, D. R. Nelson, D. R. Nelson, E. Frey, E. H. Brandt, E. Zeldov, G. Blatter, G. Carneiro, G. Williams, H. Pastoriza, H. Safar, J. Friedel, J. Friedel, J. M. Kosterlitz, J. Villain, L. Onsager, M. Franz, M. V. Feigel’man, N. Morozov, R. A. Doyle, R. Cavalcanti, R. Cavalcanti, R. E. Hetzel, R. P. Feynman, S. E. Korshunov, S. Hattel, S. Hattel, T. Chen, T. Chen, T. Chen, T. Nishikazi, U. Welp, W. Janke, Ying-Hong Li, Ying-Hong Li, Z. Tešanović   +52 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source