Results 41 to 50 of about 702,907 (282)

Critical Infrastructure Protection: Metrics and Tools [PDF]

open access: yes, 2008
Workshop organized by the Naval Postgraduate School Center for Homeland Defense and Security. Key topics of the conference included (1) Metrics, a discussion of how risk, consequence and vulnerability should be defined and measured and (2) tools ...

core  

Reiew of scientific and theoretical aspects of safety of objects of critical infrastructure of transport [PDF]

open access: yes, 2019
Проведено аналіз основних науково-теоретичних аспектів, досвіду та концепцій захисту критичної інфраструктури в Україні та світі. Визначено, що на сьогодні важливим та пріоритетним вектором безпекової політики держави є підвищення безпеки та стійкості ...
Зюзюн, Вадим Ігорович   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Protection of the upper hemisphere of a critical information infrastructure facility

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2023
Objective. Structuring of publicly available information regarding the protection of the upper hemisphere of CII objects.Method. The following methods of scientific cognition are used: systematization, description, analysis, deduction.
I. A. Loskutov, V. A. Repenko
doaj   +1 more source

Commercial critical systems and critical infrastructure protection : a future research agenda [PDF]

open access: yes, 2007
Secure management of Australia’s commercial critical infrastructure presents ongoing challenges to owners and the government. Although it is currently managed through high-level information sharing via collaboration, but does this suit the ...
Leitch, Shona, Warren, Matthew
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Protection of the national critical infrastructure [PDF]

open access: yes, 2011
Several critical infrastructures have been identifi ed in the Czech Republic that when disturbed or destroyed, they would impact on the performance of the state’s functions.
Cígler, Jaroslav   +2 more
core  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

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