Results 41 to 50 of about 712,753 (295)
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Risk assessment methodologies for critical infrastructure protection. Part II: A new approach [PDF]
, 2015 This report describes a risk assessment process for Critical Infrastructures (CI) based on the staff working document from DG ECHO namely “Risk Assessment and Mapping Guidelines for Disaster Management” and DG HOME “on a new approach to the European ...
GIANNOPOULOS Georgios +1 more
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Protection of the upper hemisphere of a critical information infrastructure facility
Вестник Дагестанского государственного технического университета: Технические науки, 2023 Objective. Structuring of publicly available information regarding the protection of the upper hemisphere of CII objects.Method. The following methods of scientific cognition are used: systematization, description, analysis, deduction.
I. A. Loskutov, V. A. Repenko
doaj +1 more source
Critical Infrastructures, Protection and Resilience [PDF]
, 2016 This chapter introduces the concept of Critical Infrastructure (CI). Although old civilisations had CI, the protection and resilience of CI has come to the fore again in the last two decades. The risk to society due to inadvertent and deliberate CI disruptions has largely increased due to interrelation, complexity, and dependencies of these ...
Setola, R. +2 more
openaire +2 more sources
STOP-IT: strategic, tactical, operational protection of water infrastructure against cyberphysical threats [PDF]
, 2018 Water supply and sanitation infrastructures are essential for our welfare, but vulnerable to several attack types facilitated by the ever-changing landscapes of the digital world.
Bonet Gil, Enrique +2 more
core +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Principles for management of risks of critical infrastructure [PDF]
, 2018 On the basis of present knowledge, the critical infrastructure is a set of physical (technical and material), cyber and organizational subsystems of human system that are necessary for ensuring the protection of: human lives, health and security ...
Procházka J. +2 more
core
Hosting critical infrastructure services in the cloud environment considerations [PDF]
Critical infrastructure technology vendors will inevitability take advantage of the benefits offered by the cloud computing paradigm. While this may offer improved performance and scalability, the associated security threats impede this progression ...
Kifayat, K +3 more
core +1 more source