Results 31 to 40 of about 46,322 (311)

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Attack Categorisation for IoT Applications in Critical Infrastructures, a Survey

Applied Sciences, 2021
With the ever advancing expansion of the Internet of Things (IoT) into our everyday lives, the number of attack possibilities increases. Furthermore, with the incorporation of the IoT into Critical Infrastructure (CI) hardware and applications, the ...
Edward Staddon, Valeria Loscri, Nathalie Mitton   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

CRITICAL INFRASTRUCTURES PROTECTION A ROMANIAN PERSPECTIVE [PDF]

Annals: Series on engineering sciences (Academy of Romanian Scientists), 2010
In each EU Member States there are a certain number of critical infrastructures, the disruption or destruction of which is essential for the maintenance of vital societal functions, health, safety, security, economic or social well-being of people, and ...
Liviu MURESAN, Septimiu CACEU
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

THE VULNERABILITY OF TRANSPORT CRITICAL INFRASTRUCTURES [PDF]

Annals: Series on engineering sciences (Academy of Romanian Scientists), 2012
Transport infrastructures belong to critical social infrastructures beside power, informational, water, gas supply infrastructures etc., whose malfunctioning could generate adverse economic, social or environmental effects.
Eugen ROŞCA, Florin RUSCĂ
doaj  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Safeguarding Critical Infrastructures: Machine Learning in Cybersecurity [PDF]

E3S Web of Conferences
It has become essential to protect vital infrastructures from cyber threats in an age where technology permeates every aspect of our lives. This article examines how machine learning and cybersecurity interact, providing a thorough overview of how this ...
Kalnawat Aarti, Dhabliya Dharmesh, Vydehi Kasichainula, Dhablia Anishkumar, Kumar Santosh D.   +4 more
doaj   +1 more source

Cloning and training collective intelligence with generative adversarial networks

IET Collaborative Intelligent Manufacturing, 2021
Industry 4.0 and highly automated critical infrastructure can be seen as cyber‐physical‐social systems controlled by the Collective Intelligence. Such systems are essential for the functioning of the society and economy.
Vagan Terziyan, Mariia Gavriushenko, Anastasiia Girka, Andrii Gontarenko, Olena Kaikova   +4 more
doaj   +1 more source