Results 41 to 50 of about 46,322 (311)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Protection of critical infrastructures and basic elements of alignment with the Council Directive 2008/114/EC [PDF]
Војно дело, 2015 The complexity of crisis and emergency situations, in particular the fact that their occurrences threaten critical assets that are essentially involved in the normal functioning process of the society, has led most states to develop a variety of ...
Škero Mirko, Ateljević Vladimir
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Preventing and Managing Risks Induced by Natural Hazards to Critical Infrastructures
Infrastructures, 2022 A procedure for assessing and monitoring the response of critical infrastructures when subjected to natural hazards is proposed in this paper, with a particular focus on bridges and viaducts, which are very peculiar and strategic assets of transport ...
Giacomo Buffarini +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
A Peer-Reviewed Journal About, 2014 The essay and ideas included here is a discussion of the topics raised through CRITICAL INFRASTRUCTURE, an artistic research and production residency that took place as part of the lead up to the transmediale festival, afterglow, 2014. The project’s initiation was about uncovering the resources and reserves of physical and material energies, signals ...
openaire +4 more sources
Cyber effect and security management aspects in critical energy infrastructures
Insights into Regional Development, 2020 The purpose of the paper is to compare various types of management models that regulate the response to cyber threats to Critical Infrastructures. The development of an effective management model that regulates the response to cyber-attack against ...
Tomas Plėta +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
On the Development of Intelligent Railway Information and Safety Systems: An Overview of Current Research [PDF]
Interdisciplinary Description of Complex Systems, 2018 The present article focuses on the research and development planning for innovative railway systems. Within such a general framework, the specific objectives of the research have been defined within the framework of a large Intelligent Railway System ...
Dániel Tokody +4 more
doaj +1 more source