Results 131 to 140 of about 5,041,885 (292)

Neuromelanin‐Sensitive MRI as a Marker of Clinical Severity and Disease Burden in Parkinson's Disease: A Systematic Review and Meta‐analysis

Movement Disorders, EarlyView.
Abstract The neuropathology of Parkinson's disease (PD) is characterized in part by the degeneration of catecholaminergic neurons, particularly dopaminergic neurons in the substantia nigra pars compacta (SNpc) and noradrenergic neurons in the locus coeruleus (LC), yet no validated in vivo biomarker quantifies this process.
Rayo Akande, Thomas Kustermann, Štefan Holiga, Judith Anzures‐Cabrera, Patrik Brundin, Gennaro Pagano   +5 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Targeted Muscle Reinnervation for Intuitive Prosthetic Control

Muscle &Nerve, EarlyView.
ABSTRACT The convergence of medical and technological advances has led to a substantial expansion of therapeutic approaches for patients with limb amputations. Targeted muscle reinnervation (TMR) is one of the strategies to improve control of bionic arms and has been applied for more than two decades. Through surgical rewiring of the nerves responsible
Nitay Maile, Laura Ferrante, Dario Farina, Ulla Al Dabbass, Oskar C. Aszmann, Vlad Tereshenko   +5 more
wiley   +1 more source

Platelet activation in bypass surgery for critical limb ischemia

Platelet activation contributes to graft occlusion after bypass surgery. This study investigated platelet activation status before, during, and after bypass. Blood was taken preoperatively from patients undergoing femoro-popliteal bypass and at incision,
Mikhailidis DP, Mohan IV, Stansby GP
core   +4 more sources

When serious becomes critical

Journal of Hospital Medicine, EarlyView.
Yohei Masuda
wiley   +1 more source

Electrophysiologic Demyelinating Features Are Common in Vasculitic Neuropathy: A Cohort of Biopsy‐Confirmed Cases

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Electrophysiologic features suggestive of demyelination have been reported in vasculitic neuropathy, complicating the diagnostic process, but their frequency is unknown. We aimed to determine the prevalence of demyelinating features, including fulfillment of European Academy of Neurology/Peripheral Nerve Society (EAN/PNS ...
Alexandra Maury, Guillemette Beaudonnet, Thierry Maisonobe, Christian Denier, Andoni Echaniz‐Laguna, Clovis Adam, Céline Labeyrie, Edouard Berling   +7 more
wiley   +1 more source

Immunomodulatory, Antibacterial, Antioxidative and EGF‐Delivering Hydrogel Remodels Wound Microenvironment for Infected Diabetic Wound Healing

National Materials, EarlyView.
In this study, we engineered an antibacterial, antioxidative and epidermal grow factor‐encapsulated multifunctional hydrogel for the repair of chronic and refractory wounds. The hydrogel markedly promoted wound healing in rat models of diabetic foot ulcers and infected wounds by modulating wound microenvironment.
Zheng Zou, Yang Gao, Desheng Qi, Zhen Zhang, Chaoliang He, Xuesi Chen   +5 more
wiley   +1 more source

The Breakthrough Balloon for Critical Limb Ischemia?

Journal of the American College of Cardiology, 2011
A true medical breakthrough represents “a sudden advance especially in knowledge or technique” ([1][1]). In the field of vascular medicine, such a breakthrough is welcome, because many of the treatments we have for peripheral artery disease (PAD) are limited.
openaire   +2 more sources

Endovascular recanalization of infra-popliteal TASC C and TASC D lesions in patients with critical limb-threatening ischemia: a single-center experience [PDF]

PURPOSE: The present study aims to (1) assess the technical success and limb salvage rates of endovascular therapy in patients with critical limb-threatening ischemia (CLTI) and infra-popliteal Trans-Atlantic Inter-Society Consensus (TASC) C/D lesions ...
Erhan Turgut Ilgıt, Ahmet Baran Önal, Ali Can Yalçın, Tolga Zeydanlı, Mustafa Hakan Zor, Abdullah Özer, Fatih Öncü, Mehmet Koray Akkan, ÖNAL, AHMET BARAN, ILGIT, ERHAN TURGUT, AKKAN, MEHMET KORAY, ÖNCÜ, FATİH, Yalçın, Ali Can, ÖZER, ABDULLAH, ZOR, MUSTAFA HAKAN, Zeydanlı, Tolga   +15 more
core   +1 more source

Improving enteral nutrition in patients requiring neurological intensive care unit care: A retrospective study on a novel bedside nasointestinal tube placement technique

Nutrition in Clinical Practice, EarlyView.
Abstract Background This study aimed to develop and assess a bedside nasojejunal tube placement technique designed for resource‐limited settings to address the specific challenges of enteral nutrition (EN) delivery in neurocritical care patients, particularly those at high risk of reflux and aspiration. The technique sought to overcome the drawbacks of
Niuchenglin, Liujuan, Zhushuibing, Dingyuanliang, Yutianhao, Shiguangling   +5 more
wiley   +1 more source