Results 101 to 110 of about 326,138 (281)

Critical associated metrics on contact manifolds III [PDF]

Journal of the Australian Mathematical Society. Series A. Pure Mathematics and Statistics, 1991
AbstractIn the first paper of this series we studied on a compact regular contact manifold the integral of the Ricci curvature in the direction of the characteristic vector field considered as a functional on the set of all associated metrics. We showed that the critical points of this functional are the metrics for which the characteristic vector ...
openaire   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Solutions for the quasi-linear elliptic problems involving the critical Sobolev exponent

Journal of Inequalities and Applications, 2017
In this article, we study the existence and multiplicity of positive solutions for the quasi-linear elliptic problems involving critical Sobolev exponent and a Hardy term.
Yanbin Sang, Siman Guo
doaj   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Structural connectome manifold changes related to body mass index and their associations with eating psychopathology

NeuroImage: Clinical
Brain connectome analysis provides insights into body mass index (BMI)-related brain topology and cognitive functions. While alterations in the brain connectome have been observed in individuals with high BMI, evidence regarding BMI-based structural ...
Yurim Jang, Jong Young Namgung, Eunchan Noh, Bo-yong Park   +3 more
doaj   +1 more source

Ground-State Solutions for a Class of N-Laplacian Equation with Critical Growth

Abstract and Applied Analysis, 2012
We investigate the existence of ground-state solutions for a class of N-Laplacian equation with critical growth in ℝN. Our proof is based on a suitable Trudinger-Moser inequality, Pohozaev-Pucci-Serrin identity manifold, and mountain pass lemma.
Guoqing Zhang, Jing Sun
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Critical quasilinear equations on Riemannian manifolds

In this paper, we investigate critical quasilinear elliptic partial differential equations on a complete Riemannian manifold with nonnegative Ricci curvature. By exploiting a new and sharp nonlinear Kato inequality and establishing some Cheng-Yau type gradient estimates for positive solutions, we classify positive solutions to the critical $p$-Laplace ...
Sun, Linlin, Wang, Youde
openaire   +2 more sources