Results 61 to 70 of about 326,138 (281)

On p-Laplace Equations with Singular Nonlinearities and Critical Sobolev Exponent

Journal of Function Spaces, 2022
In this paper, we deal with p-Laplace equations with singular nonlinearities and critical Sobolev exponent. By using the Nehari manifold, Mountain Pass theorem, and Maximum principle theorem, we prove the existence of at least four distinct nontrivial ...
Mohammed El Mokhtar ould El Mokhtar
doaj   +1 more source

Critical manifold of globally coupled overdamped anharmonic oscillators driven by additive Gaussian white noise

, 2013
We prove for an infinite array of globally coupled overdamped anharmonic oscillators subject to additive Gaussian white noise the existence of a well-behaved critical manifold in the parameter space which separates a symmetric phase from a symmetry ...
Behn, Ulrich, Gütter, Susanne, Kürsten, Rüdiger   +2 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Poles Distribution of PVI Transcendents close to a Critical Point (summer 2011)

, 2012
The distribution of the poles of branches of the Painleve' VI transcendents associated to semi-simple Frobenius manifolds is determined close to a critical point. It is shown that the poles accumulate at the critical point, asymptotically along two rays.
Brezhnev, Bruno, Bruno, Davide Guzzetti, Dubrovin, Dubrovin, Dubrovin, Dubrovin, Guzzetti, Guzzetti, Guzzetti, Guzzetti, Guzzetti, Guzzetti, Hitchin, Iwasaki, Iwasaki, Jimbo, Jimbo, Mazzocco, Mazzocco, Okamoto, Picard, Shimomura, Watanabe   +24 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Benchmarking the nonperturbative functional renormalization group approach on the random elastic manifold model in and out of equilibrium

, 2019
Criticality in the class of disordered systems comprising the random-field Ising model (RFIM) and elastic manifolds in a random environment is controlled by zero-temperature fixed points that must be treated through a functional renormalization group. We
Balog, Ivan, Tarjus, Gilles, Tissier, Matthieu   +2 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Some critical point results for Fréchet manifolds

, 2022
We prove a so-called linking theorem and some of its corollaries, namely a mountain pass theorem and a three critical points theorem for Keller $ C^1$-functional on $ C^1 $- Frechet manifolds. Our approach relies on a deformation result which is not implemented by considering the negative pseudo-gradient flows. Furthermore, for mappings between Frechet
openaire   +2 more sources

Torsion and critical metrics on contact three-manifolds [PDF]

Kodai Mathematical Journal, 1990
Let M be a 3-dimensional compact contact manifold with contact form \(\omega\) and characteristic vector field \(X_ 0\). Let \({\mathcal M}\) denote the set of all associated metrics to \(\omega\). For any \(g\in {\mathcal M}\) let r denote the scalar curvature, S the Ricci tensor, \(\tau\) the Lie derivative of g with respect to \(x_ 0\) and \(\sigma\)
openaire   +3 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source