Results 171 to 180 of about 424,711 (307)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Heart Rate Variability and Body Motion as Digital Biomarkers of Task Workload During Military En Route Critical Care Simulations. [PDF]

Sensors (Basel)
Dias RD, Michael SH, Harari R, Yule S, McGinnis L, Skipworth RJE, Mann-Salinas E, Davis WT.   +7 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A critical edition of Derek Walcott's Omeros [PDF]

The thesis is a Critical Edition of Derek Walcott’s Omeros, consisting of a Critical Introduction and Annotations. The Critical Introduction analyses: - Narrative - Settings - Metaphor and Paronomasia - Symbolism - Historiography - Intertexts ...
Barnard, Donald Edwin
core  

Acute Ischemic Stroke Lesion Characterization: Comparative Analysis of Cortical and Basal Ganglia Lesions Using Time-Histogram Metrics. [PDF]

Diagnostics (Basel)
Liu HM, Tseng WL.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The illusory correlation between geometrical similarity and physician satisfaction in heart auto-segmentation revealed by a physician-blind test. [PDF]

J Appl Clin Med Phys
Lee JC, Heo EJ, Cho SH, Lee DY, Chang KH, Shim JB, Lee NK, Lee S.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

High quality care metrics for nursing [PDF]

, 2012
Maben, Jill, Robert, Glenn, Morrow, Elizabeth, Ball, Jane, Griffiths, Peter   +4 more
core  

Subthalamic segmentations in relation to deep brain stimulation volumes in Parkinson's disease. [PDF]

Acta Neurochir (Wien)
Calvano A, Xiao Y, Steidel K, Loehrer PA, Ruppert-Junck MC, Nimsky C, Timmermann L, Bopp MHA, Pedrosa DJ.   +8 more
europepmc   +1 more source