Results 61 to 70 of about 5,715,087 (351)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Critical phenomena and critical relations

, 2002
We consider systems which exhibit typical critical dependence of the specific heat: $ c\varpropto (T_C-T)^{- }$ ($TT_C$) where $ $,$ ^{\prime}$ are critical exponents ($ = $ for $ c= c_{p,N},$ $ =\bar $ for $ c= c_{V,N}$), as well as, the case when $ c\varpropto (\ln \mid T_C-T\mid)^a$ ($% a=\frac 13$, uniaxial ferroelectrics; $a=1 ...
Matlak, M., Grabiec, B.
openaire   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Scaling Laws in the Fine-Scale Structure of Range Margins

Mathematics, 2018
Margins of the geographic distributions of species are important regions in terms of ecological and evolutionary processes, including the species’ response to climate change. This paper reviews some spatially explicit metapopulation models of range
Beáta Oborny
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Analysis of the 3d massive renormalization group perturbative expansions: a delicate case

Condensed Matter Physics, 2010
The effectiveness of the perturbative renormalization group approach at fixed space dimension d in the theory of critical phenomena is analyzed. Three models are considered: the O(N) model, the cubic model and the antiferromagnetic model defined on the ...
B. Delamotte, M. Dudka, Yu. Holovatch, D. Mouhanna   +3 more
doaj   +1 more source

Multiple‐Instance Superparameterization: 1. Concept, and Predictability of Precipitation

Journal of Advances in Modeling Earth Systems, 2019
We have investigated the predictability of precipitation using a new configuration of the superparameterized Community Atmosphere Model (SP‐CAM). The new configuration, called the multiple‐instance SP‐CAM, or MP‐CAM, uses the average heating and drying ...
Todd R. Jones, David A. Randall, Mark D. Branson   +2 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source