Results 71 to 80 of about 361,254 (268)

Cognitive outcome after awake surgery for left and right hemisphere tumours

Frontiers in Psychology, 2015
INTRODUCTION: Awake surgery in eloquent brain regions is performed to preserve language and other cognitive functions. Although in general, no major permanent cognitive deficits are found after awake brain surgery, clinically relevant impairments are ...
Elke De Witte, Djaina Satoer, Djaina Satoer, Peter Mariën   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Rapid recovery from aphasia after infarction of Wernicke’s area

Frontiers in Psychology, 2015
Introduction Wernicke’s area (the posterior superior temporal gyrus) is a critical brain region for language. However language function does recover over time to varying extents in many patients with damage to Wernicke’s area (Kertesz et al., 1993).
Melodie Yen, Stephen M Wilson, Stephen M Wilson   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reading a Protoevangelium in the Context of Genesis [PDF]

, 2014
This article proposes that the case for a ‘messianic’ reading of Gen. 3:15 is cumulative. No single individual argument is decisive and it is virtually impossible to sustain a robust protevangelium interpretation of this text within the context of Gen. 3
Pettus, David
core   +1 more source

Attention please: evaluative priming effects in a valent/non-valent categorization task (Reply to Werner and Rothermund, 2013) [PDF]

, 2013
It has previously been argued (a) that automatic evaluative stimulus processing is dependent upon feature-specific attention allocation (FSAA) and (b) that evaluative priming effects can arise in the absence of dimensional overlap between the prime set ...
Spruyt, Adriaan
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Deficits of knowledge versus executive control in semantic cognition: Insights from cued naming [PDF]

, 2007
Deficits of semantic cognition in semantic dementia and in aphasia consequent on CVA (stroke) are qualitatively different. Patients with semantic dementia are characterised by progressive degradation of central semantic representations, whereas ...
Baayen, Berthier, Bozeat, Burgess, Burgess, Chertkow, Crutch, Damasio, Damasio, Dell, Dell, Demb, Elizabeth Jefferies, Folstein, Forde, Foygel, Funnell, Gloor, Gold, Goodglass, Graham, Hart, Hodges, Howard, Jefferies, Jefferies, Jefferies, Jefferies, Kaplan, Karalyn Patterson, Kay, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lambon Ralph, Martin, Matthew A. Lambon Ralph, Milner, Mummery, Myers Pease, Nestor, Parker, Patterson, Peers, Podraza, Raven, Robertson, Robinson, Robinson, Rogers, Saffran, Saygin, Schwartz, Snodgrass, Snowden, Stuss, Thompson-Schill, Thompson-Schill, Wagner, Warrington, Warrington, Wechsler, Wernicke   +62 more
core   +3 more sources