Results 181 to 190 of about 1,449,299 (326)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Laser-Assisted Diamond Turning for Anisotropy Suppression in Calcium Fluoride. [PDF]

open access: yesMicromachines (Basel)
Xing E   +10 more
europepmc   +1 more source

Joined application of a multiaxial critical plane criterion and a strain energy density criterion in low-cycle fatigue

open access: diamond, 2017
Andrea Carpinteri   +5 more
openalex   +2 more sources

Testing 4-critical plane and projective plane multiwheels using Mathematica

open access: yes, 2015
In this article we explore 4-critical graphs using Mathematica. We generate graph patterns according [1, D. Zeps. On building 4-critical plane and projective plane multiwheels from odd wheels, arXiv:1202.4862v1]. Using the base graph, minimal planar multiwheel and in the same time minimal according projective pattern built multiwheel, we build minimal ...
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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