Results 221 to 230 of about 7,571,221 (346)

Spatial control over near-critical-point operation ensures fidelity of ParABS-mediated DNA partition. [PDF]

Biophys J, 2021
Hu L, Rech J, Bouet JY, Liu J.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Maximal isometric and eccentric hamstring strength is influenced by body mass and additional load: Does the critical point at which peak knee flexor force is achieved play a role? [PDF]

Front Physiol
Sinulingga AR, Zemková E.
europepmc   +1 more source

Functional advantages of Lévy walks emerging near a critical point. [PDF]

Proc Natl Acad Sci U S A, 2020
Abe MS.
europepmc   +1 more source

Ultra-Narrow Metallic Nano-Trenches Realized by Wet Etching and Critical Point Drying. [PDF]

Nanomaterials (Basel), 2021
Jeong J, Yang H, Park S, Park YD, Kim DS.   +4 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Poincaré-Bendixson Theorem: from Poincaré to the XXIst century

Open Mathematics, 2012
Ciesielski Krzysztof
doaj   +1 more source

Ferromagnetic quantum critical point protected by nonsymmorphic symmetry in a Kondo metal. [PDF]

Nat Commun
Shin S, Ramires A, Pomjakushin V, Plokhikh I, Pomjakushina E.   +4 more
europepmc   +1 more source

Level sets lemmas and unicity of critical point of invariants, tools for local stability and topological properties of dynamical systems

, 2012
Guy Bastien, Marc Rogalski
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source