Results 241 to 250 of about 16,818,507 (390)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Critical point for Bose-Einstein condensation of excitons in graphite. [PDF]

Proc Natl Acad Sci U S A, 2020
Wang J, Nie P, Li X, Zuo H, Fauqué B, Zhu Z, Behnia K.   +6 more
europepmc   +1 more source

Critical Point-Finding Methods Reveal Gradient-Flat Regions of Deep Network Losses. [PDF]

Neural Comput, 2021
Frye CG, Simon J, Wadia NS, Ligeralde A, DeWeese MR, Bouchard KE.   +5 more
europepmc   +1 more source

Histological analysis of the ‘critical point’ in follicular development in mice [PDF]

, 2004
Satosi KAGABU, Motoaki UMEZU
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Replacing critical point drying with hexamethyldisilazane drying enhances the ultrastructural preservation of cell surface projections in the parasite Trichomonas vaginalis for scanning electron microscopy. [PDF]

PLoS One
Dos Santos Melo T, Miranda-Magalhães A, Celia Bressan Queiroz de Figueiredo R, Pereira-Neves A.   +3 more
europepmc   +1 more source

Spatial control over near-critical-point operation ensures fidelity of ParABS-mediated DNA partition. [PDF]

Biophys J, 2021
Hu L, Rech J, Bouet JY, Liu J.
europepmc   +1 more source

Fluctuation-Induced Heat Release from Temperature-Quenched Nuclear Spins near a Quantum Critical Point

, 2009
Y. H. Kim, Navneet Kaur, B. M. Atkins, N.S. Dalal, Y. Takano   +4 more
openalex   +1 more source

The Critical Point

, 2022
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source