Results 51 to 60 of about 10,934,305 (297)

Criticality Controlling Mechanisms in Nematic Liquid Crystals

open access: yesNanomaterials
We theoretically study the generic mechanisms that could establish critical behavior in nematic liquid crystals (NLCs). The corresponding free energy density terms should exhibit linear coupling with the nematic order parameter and, via this coupling ...
Maha Zid   +3 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Existence of periodic solutions with prescribed minimal period of a 2nth-order discrete system

open access: yesOpen Mathematics, 2019
In this paper, we concern with a 2nth-order discrete system. Using the critical point theory, we establish various sets of sufficient conditions for the existence of periodic solutions with prescribed minimal period. To the best of our knowledge, this is
Liu Xia, Zhou Tao, Shi Haiping
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Homoclinic solutions for second-order non-autonomous Hamiltonian systems without global Ambrosetti-Rabinowitz conditions

open access: yesElectronic Journal of Differential Equations, 2010
This article studies the existence of homoclinic solutions for the second-order non-autonomous Hamiltonian system $$ ddot q-L(t)q+W_{q}(t,q)=0, $$ where $Lin C(mathbb{R},mathbb{R}^{n^2})$ is a symmetric and positive definite matrix for all $tin ...
Rong Yuan, Ziheng Zhang
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Brezis-Nirenberg problem on hyperbolic spaces

open access: yesElectronic Journal of Differential Equations, 2019
We consider a Brezis-Nirenberg problem on the hyperbolic space $\mathbb{H}^n$. By using the stereographic projection, the problem becomes a singular problem on the boundary of the open ball $B_1(0)\subset \mathbb{R}^n$. Thanks to the Hardy inequality,
Paulo C. Carriao   +3 more
doaj  

Symmetry & Critical Points

open access: yesCoRR
Critical points of an invariant function may or may not be symmetric. We prove, however, that if a symmetric critical point exists, those adjacent to it are generically symmetry breaking. This mathematical mechanism is shown to carry important implications for our ability to efficiently minimize invariant nonconvex functions, in particular those ...
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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