Mechanics Predicts Effective Critical-Size Bone Regeneration Using 3D-Printed Bioceramic Scaffolds
Abstract BACKGROUND: 3D-printed bioceramic scaffolds have gained popularity due to their controlled microarchitecture and their proven biocompatibility. However, their high brittleness makes their surgical implementation complex for weight-bearing bone treatments.
Pablo Blázquez-Carmona +5 more
openaire +6 more sources
Functionalized 3D-Printed PLA Biomimetic Scaffold for Repairing Critical-Size Bone Defects
The treatment of critical-size bone defects remains a complicated clinical challenge. Recently, bone tissue engineering has emerged as a potential therapeutic approach for defect repair. This study examined the biocompatibility and repair efficacy of hydroxyapatite-mineralized bionic polylactic acid (PLA) scaffolds, which were prepared through a ...
Xiao Liu +8 more
openaire +3 more sources
Distance word acuity, critical print size and driving vision standards [PDF]
A comparison was made between letter visual acuity and word acuity at distance and between letter acuity and the minimum word size allowing maximum and fluent reading speeds.Visual acuities were measured at six metres for 120 participants. Letter acuity was assessed with a logMAR layout chart with Sloan letters displayed with Thomson XPert software.
Sheila, Rae +2 more
openaire +2 more sources
3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions
The management and definitive treatment of segmental bone defects in the setting of acute trauma, fracture non-union, revision joint arthroplasty, and tumor surgery are challenging clinical problems with no consistently satisfactory solution. Orthopaedic surgeons are developing novel strategies to treat these problems, including three-dimensional (3D ...
Cory K. Mayfield +4 more
openaire +3 more sources
Three dimensionally printed bioactive ceramic scaffold osseoconduction across critical-sized mandibular defects [PDF]
Vascularized bone tissue transfer, commonly used to reconstruct large mandibular defects, is challenged by long operative times, extended hospital stay, donor-site morbidity, and resulting health care. 3D-printed osseoconductive tissue-engineered scaffolds may provide an alternative solution for reconstruction of significant mandibular defects.
Christopher D. Lopez +8 more
openaire +2 more sources
Design and 3D Printing of Personalized Hybrid and Gradient Structures for Critical Size Bone Defects
Treating critical-size bone defects with autografts, allografts, or standardized implants is challenging since the healing of the defect area necessitates patient-specific grafts with mechanically and physiologically relevant structures. Three-dimensional (3D) printing using computer-aided design (CAD) is a promising approach for bone tissue ...
Mine Altunbek +4 more
openaire +4 more sources
3D-printed scaffold combined to 2D osteoinductive coatings to repair a critical-size mandibular bone defect [PDF]
Abstractthe reconstruction of large bone defects (12 cm3) remains a challenge for clinicians. We developed a new critical-size mandibular bone defect model on a mini-pig, close to human clinical issues. We analyzed the bone reconstruction obtained by a 3D printed scaffold made of clinical-grade PLA, coated with a polyelectrolyte film delivering an ...
M. Bouyer +9 more
openaire +5 more sources
Repair of Critical‐Sized Long Bone Defects Using Dipyridamole‐Augmented 3D‐Printed Bioactive Ceramic Scaffolds [PDF]
ABSTRACTThere are over two million long bone defects treated in the United States annually, of which ~5% will not heal without significant surgical intervention. While autogenous grafting is the standard of care in simple defects, a customized scaffold for large defects in unlimited quantities is not available.
Lukasz Witek +6 more
openaire +2 more sources
Cyclic dominance and biodiversity in well-mixed populations [PDF]
Coevolutionary dynamics is investigated in chemical catalysis, biological evolution, social and economic systems. The dynamics of these systems can be analyzed within the unifying framework of evolutionary game theory.
Claussen, Jens Christian, Traulsen, Arne
core +2 more sources
Evaluating the Effectiveness of an Established Community-Based Eccentric Viewing Rehabilitation Training Model—the EValuation Study [PDF]
Purpose: This study evaluated the community-based eccentric viewing (EV) training offered across the United Kingdom by the Macular Society. Volunteer trainers deliver free one-to-one training, usually in learners' homes. They also share information about
Dickinson, C. +2 more
core +1 more source

